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EncoMPASS: an online database for analyzing structure and symmetry in membrane proteins

The EncoMPASS online database (http://encompass.ninds.nih.gov) collects, organizes, and presents information about membrane proteins of known structure, emphasizing their structural similarities as well as their quaternary and internal symmetries. Unlike, e.g. SCOP, the EncoMPASS database does not a...

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Detalles Bibliográficos
Autores principales: Sarti, Edoardo, Aleksandrova, Antoniya A, Ganta, Srujan K, Yavatkar, Amarendra S, Forrest, Lucy R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323976/
https://www.ncbi.nlm.nih.gov/pubmed/30357403
http://dx.doi.org/10.1093/nar/gky952
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author Sarti, Edoardo
Aleksandrova, Antoniya A
Ganta, Srujan K
Yavatkar, Amarendra S
Forrest, Lucy R
author_facet Sarti, Edoardo
Aleksandrova, Antoniya A
Ganta, Srujan K
Yavatkar, Amarendra S
Forrest, Lucy R
author_sort Sarti, Edoardo
collection PubMed
description The EncoMPASS online database (http://encompass.ninds.nih.gov) collects, organizes, and presents information about membrane proteins of known structure, emphasizing their structural similarities as well as their quaternary and internal symmetries. Unlike, e.g. SCOP, the EncoMPASS database does not aim for a strict classification of membrane proteins, but instead is organized as a protein chain-centric network of sequence and structural homologues. The online server for the EncoMPASS database provides tools for comparing the structural features of its entries, making it a useful resource for homology modeling and active site identification studies. The database can also be used for inferring functionality, which for membrane proteins often involves symmetry-related mechanisms. To this end, the online database also provides a comprehensive description of both the quaternary and internal symmetries in known membrane protein structures, with a particular focus on their orientation relative to the membrane.
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spelling pubmed-63239762019-01-10 EncoMPASS: an online database for analyzing structure and symmetry in membrane proteins Sarti, Edoardo Aleksandrova, Antoniya A Ganta, Srujan K Yavatkar, Amarendra S Forrest, Lucy R Nucleic Acids Res Database Issue The EncoMPASS online database (http://encompass.ninds.nih.gov) collects, organizes, and presents information about membrane proteins of known structure, emphasizing their structural similarities as well as their quaternary and internal symmetries. Unlike, e.g. SCOP, the EncoMPASS database does not aim for a strict classification of membrane proteins, but instead is organized as a protein chain-centric network of sequence and structural homologues. The online server for the EncoMPASS database provides tools for comparing the structural features of its entries, making it a useful resource for homology modeling and active site identification studies. The database can also be used for inferring functionality, which for membrane proteins often involves symmetry-related mechanisms. To this end, the online database also provides a comprehensive description of both the quaternary and internal symmetries in known membrane protein structures, with a particular focus on their orientation relative to the membrane. Oxford University Press 2019-01-08 2018-10-24 /pmc/articles/PMC6323976/ /pubmed/30357403 http://dx.doi.org/10.1093/nar/gky952 Text en Published by Oxford University Press on behalf of Nucleic Acids Research 2018. This work is written by (a) US Government employee(s) and is in the public domain in the US.
spellingShingle Database Issue
Sarti, Edoardo
Aleksandrova, Antoniya A
Ganta, Srujan K
Yavatkar, Amarendra S
Forrest, Lucy R
EncoMPASS: an online database for analyzing structure and symmetry in membrane proteins
title EncoMPASS: an online database for analyzing structure and symmetry in membrane proteins
title_full EncoMPASS: an online database for analyzing structure and symmetry in membrane proteins
title_fullStr EncoMPASS: an online database for analyzing structure and symmetry in membrane proteins
title_full_unstemmed EncoMPASS: an online database for analyzing structure and symmetry in membrane proteins
title_short EncoMPASS: an online database for analyzing structure and symmetry in membrane proteins
title_sort encompass: an online database for analyzing structure and symmetry in membrane proteins
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323976/
https://www.ncbi.nlm.nih.gov/pubmed/30357403
http://dx.doi.org/10.1093/nar/gky952
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