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Genenames.org: the HGNC and VGNC resources in 2019

The HUGO Gene Nomenclature Committee (HGNC) based at EMBL’s European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 40 000 approved gene symbols in our current database of which over 19 000 are for protein-coding genes. The Vertebrate Gene Nomencl...

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Autores principales: Braschi, Bryony, Denny, Paul, Gray, Kristian, Jones, Tamsin, Seal, Ruth, Tweedie, Susan, Yates, Bethan, Bruford, Elspeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324057/
https://www.ncbi.nlm.nih.gov/pubmed/30304474
http://dx.doi.org/10.1093/nar/gky930
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author Braschi, Bryony
Denny, Paul
Gray, Kristian
Jones, Tamsin
Seal, Ruth
Tweedie, Susan
Yates, Bethan
Bruford, Elspeth
author_facet Braschi, Bryony
Denny, Paul
Gray, Kristian
Jones, Tamsin
Seal, Ruth
Tweedie, Susan
Yates, Bethan
Bruford, Elspeth
author_sort Braschi, Bryony
collection PubMed
description The HUGO Gene Nomenclature Committee (HGNC) based at EMBL’s European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 40 000 approved gene symbols in our current database of which over 19 000 are for protein-coding genes. The Vertebrate Gene Nomenclature Committee (VGNC) was established in 2016 to assign standardized nomenclature in line with human for vertebrate species that lack their own nomenclature committees. The VGNC initially assigned nomenclature for over 15000 protein-coding genes in chimpanzee. We have extended this process to other vertebrate species, naming over 14000 protein-coding genes in cow and dog and over 13 000 in horse to date. Our HGNC website https://www.genenames.org has undergone a major design update, simplifying the homepage to provide easy access to our search tools and making the site more mobile friendly. Our gene families pages are now known as ‘gene groups’ and have increased in number to over 1200, with nearly half of all named genes currently assigned to at least one gene group. This article provides an overview of our online data and resources, focusing on our work over the last two years.
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spelling pubmed-63240572019-01-10 Genenames.org: the HGNC and VGNC resources in 2019 Braschi, Bryony Denny, Paul Gray, Kristian Jones, Tamsin Seal, Ruth Tweedie, Susan Yates, Bethan Bruford, Elspeth Nucleic Acids Res Database Issue The HUGO Gene Nomenclature Committee (HGNC) based at EMBL’s European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 40 000 approved gene symbols in our current database of which over 19 000 are for protein-coding genes. The Vertebrate Gene Nomenclature Committee (VGNC) was established in 2016 to assign standardized nomenclature in line with human for vertebrate species that lack their own nomenclature committees. The VGNC initially assigned nomenclature for over 15000 protein-coding genes in chimpanzee. We have extended this process to other vertebrate species, naming over 14000 protein-coding genes in cow and dog and over 13 000 in horse to date. Our HGNC website https://www.genenames.org has undergone a major design update, simplifying the homepage to provide easy access to our search tools and making the site more mobile friendly. Our gene families pages are now known as ‘gene groups’ and have increased in number to over 1200, with nearly half of all named genes currently assigned to at least one gene group. This article provides an overview of our online data and resources, focusing on our work over the last two years. Oxford University Press 2019-01-08 2018-10-10 /pmc/articles/PMC6324057/ /pubmed/30304474 http://dx.doi.org/10.1093/nar/gky930 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database Issue
Braschi, Bryony
Denny, Paul
Gray, Kristian
Jones, Tamsin
Seal, Ruth
Tweedie, Susan
Yates, Bethan
Bruford, Elspeth
Genenames.org: the HGNC and VGNC resources in 2019
title Genenames.org: the HGNC and VGNC resources in 2019
title_full Genenames.org: the HGNC and VGNC resources in 2019
title_fullStr Genenames.org: the HGNC and VGNC resources in 2019
title_full_unstemmed Genenames.org: the HGNC and VGNC resources in 2019
title_short Genenames.org: the HGNC and VGNC resources in 2019
title_sort genenames.org: the hgnc and vgnc resources in 2019
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324057/
https://www.ncbi.nlm.nih.gov/pubmed/30304474
http://dx.doi.org/10.1093/nar/gky930
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