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Surgical outcomes of repeat trabeculectomy augmented with high dose mitomycin C
PURPOSE: To evaluate the surgical outcomes of repeat trabeculectomy augmented with risk factor adjusted mitomycin C (MMC) exposure in eyes with previous failed trabeculectomy. METHODS: Case records of 38 eyes of 37 patients with previous failed filter who underwent repeat trabeculectomy with MMC wer...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324121/ https://www.ncbi.nlm.nih.gov/pubmed/30574901 http://dx.doi.org/10.4103/ijo.IJO_682_18 |
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author | Rajendrababu, Sharmila Shroff, Sujani Patil, Sangeeta Vivek Uduman, Mohammed Sithiq Vardhan, Ashok Krishnadas, S R |
author_facet | Rajendrababu, Sharmila Shroff, Sujani Patil, Sangeeta Vivek Uduman, Mohammed Sithiq Vardhan, Ashok Krishnadas, S R |
author_sort | Rajendrababu, Sharmila |
collection | PubMed |
description | PURPOSE: To evaluate the surgical outcomes of repeat trabeculectomy augmented with risk factor adjusted mitomycin C (MMC) exposure in eyes with previous failed trabeculectomy. METHODS: Case records of 38 eyes of 37 patients with previous failed filter who underwent repeat trabeculectomy with MMC were reviewed retrospectively. Main outcome measures were best-corrected visual acuity (BCVA), intraocular pressure (IOP) reduction, requirement of anti-glaucoma medications, postoperative complications, and surgical success (defined as IOP of ≤21 mmHg and >5 mmHg along with 20% reduction from preoperative IOP with or without adjuvant medications) at 1-year postoperatively. Statistical analysis was done using the STATA 14.1 (Texas, USA). RESULTS: Patient's mean age was 46.41 (±20.43) years and the mean preoperative IOP was 32.73 (±9.26) mmHg which reduced to 16.22 (±7.08) mmHg postoperatively at 12 months (P < 0.001). Mean number of anti-glaucoma medications reduced from 2.76 (±0.83) preoperatively to 1.89 (±0.95) postoperatively (P < 0.001). Surgical success was observed in 81.1% at 1 year (n = 30). Eyes that received MMC >3 min had a postoperative mean IOP of 12.50 (±3.23) mmHg compared to 23.08 (±7.19) mmHg with MMC <3 min (P < 0.001). Seven eyes (18.4%) developed postoperative complications, and all were seen in eyes that received MMC >3 min (P = 0.033). CONCLUSION: Repeat trabeculectomy with MMC, used in higher concentration and exposure time altered according to individual risk factor plays a crucial role in the success and hence it could be considered as a viable option before planning a tube surgery. |
format | Online Article Text |
id | pubmed-6324121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-63241212019-01-25 Surgical outcomes of repeat trabeculectomy augmented with high dose mitomycin C Rajendrababu, Sharmila Shroff, Sujani Patil, Sangeeta Vivek Uduman, Mohammed Sithiq Vardhan, Ashok Krishnadas, S R Indian J Ophthalmol Original Article PURPOSE: To evaluate the surgical outcomes of repeat trabeculectomy augmented with risk factor adjusted mitomycin C (MMC) exposure in eyes with previous failed trabeculectomy. METHODS: Case records of 38 eyes of 37 patients with previous failed filter who underwent repeat trabeculectomy with MMC were reviewed retrospectively. Main outcome measures were best-corrected visual acuity (BCVA), intraocular pressure (IOP) reduction, requirement of anti-glaucoma medications, postoperative complications, and surgical success (defined as IOP of ≤21 mmHg and >5 mmHg along with 20% reduction from preoperative IOP with or without adjuvant medications) at 1-year postoperatively. Statistical analysis was done using the STATA 14.1 (Texas, USA). RESULTS: Patient's mean age was 46.41 (±20.43) years and the mean preoperative IOP was 32.73 (±9.26) mmHg which reduced to 16.22 (±7.08) mmHg postoperatively at 12 months (P < 0.001). Mean number of anti-glaucoma medications reduced from 2.76 (±0.83) preoperatively to 1.89 (±0.95) postoperatively (P < 0.001). Surgical success was observed in 81.1% at 1 year (n = 30). Eyes that received MMC >3 min had a postoperative mean IOP of 12.50 (±3.23) mmHg compared to 23.08 (±7.19) mmHg with MMC <3 min (P < 0.001). Seven eyes (18.4%) developed postoperative complications, and all were seen in eyes that received MMC >3 min (P = 0.033). CONCLUSION: Repeat trabeculectomy with MMC, used in higher concentration and exposure time altered according to individual risk factor plays a crucial role in the success and hence it could be considered as a viable option before planning a tube surgery. Medknow Publications & Media Pvt Ltd 2019-01 /pmc/articles/PMC6324121/ /pubmed/30574901 http://dx.doi.org/10.4103/ijo.IJO_682_18 Text en Copyright: © 2018 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Rajendrababu, Sharmila Shroff, Sujani Patil, Sangeeta Vivek Uduman, Mohammed Sithiq Vardhan, Ashok Krishnadas, S R Surgical outcomes of repeat trabeculectomy augmented with high dose mitomycin C |
title | Surgical outcomes of repeat trabeculectomy augmented with high dose mitomycin C |
title_full | Surgical outcomes of repeat trabeculectomy augmented with high dose mitomycin C |
title_fullStr | Surgical outcomes of repeat trabeculectomy augmented with high dose mitomycin C |
title_full_unstemmed | Surgical outcomes of repeat trabeculectomy augmented with high dose mitomycin C |
title_short | Surgical outcomes of repeat trabeculectomy augmented with high dose mitomycin C |
title_sort | surgical outcomes of repeat trabeculectomy augmented with high dose mitomycin c |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324121/ https://www.ncbi.nlm.nih.gov/pubmed/30574901 http://dx.doi.org/10.4103/ijo.IJO_682_18 |
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