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Perspective: The role of mechanobiology in the etiology of brain metastasis

Tumor latency and dormancy are obstacles to effective cancer treatment. In brain metastases, emergence of a lesion can occur at varying intervals from diagnosis and in some cases following successful treatment of the primary tumor. Genetic factors that drive brain metastases have been identified, su...

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Autor principal: Tanner, Kandice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324204/
https://www.ncbi.nlm.nih.gov/pubmed/31069312
http://dx.doi.org/10.1063/1.5024394
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author Tanner, Kandice
author_facet Tanner, Kandice
author_sort Tanner, Kandice
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description Tumor latency and dormancy are obstacles to effective cancer treatment. In brain metastases, emergence of a lesion can occur at varying intervals from diagnosis and in some cases following successful treatment of the primary tumor. Genetic factors that drive brain metastases have been identified, such as those involved in cell adhesion, signaling, extravasation, and metabolism. From this wealth of knowledge, vexing questions still remain; why is there a difference in strategy to facilitate outgrowth and why is there a difference in latency? One missing link may be the role of tissue biophysics of the brain microenvironment in infiltrating cells. Here, I discuss the mechanical cues that may influence disseminated tumor cells in the brain, as a function of age and disease. I further discuss in vitro and in vivo preclinical models such as 3D culture systems and zebrafish to study the role of the mechanical environment in brain metastasis in an effort of providing novel targeted therapeutics.
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spelling pubmed-63242042019-05-08 Perspective: The role of mechanobiology in the etiology of brain metastasis Tanner, Kandice APL Bioeng Special Topic: Bioengineering of Cancer Tumor latency and dormancy are obstacles to effective cancer treatment. In brain metastases, emergence of a lesion can occur at varying intervals from diagnosis and in some cases following successful treatment of the primary tumor. Genetic factors that drive brain metastases have been identified, such as those involved in cell adhesion, signaling, extravasation, and metabolism. From this wealth of knowledge, vexing questions still remain; why is there a difference in strategy to facilitate outgrowth and why is there a difference in latency? One missing link may be the role of tissue biophysics of the brain microenvironment in infiltrating cells. Here, I discuss the mechanical cues that may influence disseminated tumor cells in the brain, as a function of age and disease. I further discuss in vitro and in vivo preclinical models such as 3D culture systems and zebrafish to study the role of the mechanical environment in brain metastasis in an effort of providing novel targeted therapeutics. AIP Publishing LLC 2018-05-08 /pmc/articles/PMC6324204/ /pubmed/31069312 http://dx.doi.org/10.1063/1.5024394 Text en © 2018 Author(s). 2473-2877/2018/2(3)/031801/14 All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Special Topic: Bioengineering of Cancer
Tanner, Kandice
Perspective: The role of mechanobiology in the etiology of brain metastasis
title Perspective: The role of mechanobiology in the etiology of brain metastasis
title_full Perspective: The role of mechanobiology in the etiology of brain metastasis
title_fullStr Perspective: The role of mechanobiology in the etiology of brain metastasis
title_full_unstemmed Perspective: The role of mechanobiology in the etiology of brain metastasis
title_short Perspective: The role of mechanobiology in the etiology of brain metastasis
title_sort perspective: the role of mechanobiology in the etiology of brain metastasis
topic Special Topic: Bioengineering of Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324204/
https://www.ncbi.nlm.nih.gov/pubmed/31069312
http://dx.doi.org/10.1063/1.5024394
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