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Perspective: The role of mechanobiology in the etiology of brain metastasis
Tumor latency and dormancy are obstacles to effective cancer treatment. In brain metastases, emergence of a lesion can occur at varying intervals from diagnosis and in some cases following successful treatment of the primary tumor. Genetic factors that drive brain metastases have been identified, su...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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AIP Publishing LLC
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324204/ https://www.ncbi.nlm.nih.gov/pubmed/31069312 http://dx.doi.org/10.1063/1.5024394 |
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author | Tanner, Kandice |
author_facet | Tanner, Kandice |
author_sort | Tanner, Kandice |
collection | PubMed |
description | Tumor latency and dormancy are obstacles to effective cancer treatment. In brain metastases, emergence of a lesion can occur at varying intervals from diagnosis and in some cases following successful treatment of the primary tumor. Genetic factors that drive brain metastases have been identified, such as those involved in cell adhesion, signaling, extravasation, and metabolism. From this wealth of knowledge, vexing questions still remain; why is there a difference in strategy to facilitate outgrowth and why is there a difference in latency? One missing link may be the role of tissue biophysics of the brain microenvironment in infiltrating cells. Here, I discuss the mechanical cues that may influence disseminated tumor cells in the brain, as a function of age and disease. I further discuss in vitro and in vivo preclinical models such as 3D culture systems and zebrafish to study the role of the mechanical environment in brain metastasis in an effort of providing novel targeted therapeutics. |
format | Online Article Text |
id | pubmed-6324204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | AIP Publishing LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-63242042019-05-08 Perspective: The role of mechanobiology in the etiology of brain metastasis Tanner, Kandice APL Bioeng Special Topic: Bioengineering of Cancer Tumor latency and dormancy are obstacles to effective cancer treatment. In brain metastases, emergence of a lesion can occur at varying intervals from diagnosis and in some cases following successful treatment of the primary tumor. Genetic factors that drive brain metastases have been identified, such as those involved in cell adhesion, signaling, extravasation, and metabolism. From this wealth of knowledge, vexing questions still remain; why is there a difference in strategy to facilitate outgrowth and why is there a difference in latency? One missing link may be the role of tissue biophysics of the brain microenvironment in infiltrating cells. Here, I discuss the mechanical cues that may influence disseminated tumor cells in the brain, as a function of age and disease. I further discuss in vitro and in vivo preclinical models such as 3D culture systems and zebrafish to study the role of the mechanical environment in brain metastasis in an effort of providing novel targeted therapeutics. AIP Publishing LLC 2018-05-08 /pmc/articles/PMC6324204/ /pubmed/31069312 http://dx.doi.org/10.1063/1.5024394 Text en © 2018 Author(s). 2473-2877/2018/2(3)/031801/14 All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Special Topic: Bioengineering of Cancer Tanner, Kandice Perspective: The role of mechanobiology in the etiology of brain metastasis |
title | Perspective: The role of mechanobiology in the etiology of brain
metastasis |
title_full | Perspective: The role of mechanobiology in the etiology of brain
metastasis |
title_fullStr | Perspective: The role of mechanobiology in the etiology of brain
metastasis |
title_full_unstemmed | Perspective: The role of mechanobiology in the etiology of brain
metastasis |
title_short | Perspective: The role of mechanobiology in the etiology of brain
metastasis |
title_sort | perspective: the role of mechanobiology in the etiology of brain
metastasis |
topic | Special Topic: Bioengineering of Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324204/ https://www.ncbi.nlm.nih.gov/pubmed/31069312 http://dx.doi.org/10.1063/1.5024394 |
work_keys_str_mv | AT tannerkandice perspectivetheroleofmechanobiologyintheetiologyofbrainmetastasis |