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Toxicity Effect of Sub-Chronic Oral Administration of Class Bitters® - A Polyherbal Formula on Serum Electrolytes and Hematological Indices in Male Wistar Albino Rats
The indiscriminate administration of ready-to-use herbal formulations has become a major concern due to their potential health risk. The study investigated the effect of class bitters(®) (CB) - a polyherbal formula prepared with Mondia whitei, Khaya senegalensis, Capparis erythrocarpus, Thoningia sa...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324464/ https://www.ncbi.nlm.nih.gov/pubmed/30701040 http://dx.doi.org/10.4081/xeno.2015.5369 |
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author | Patrick-Iwuanyanwu, Kingsley C. Nkpaa, Kpobari W. |
author_facet | Patrick-Iwuanyanwu, Kingsley C. Nkpaa, Kpobari W. |
author_sort | Patrick-Iwuanyanwu, Kingsley C. |
collection | PubMed |
description | The indiscriminate administration of ready-to-use herbal formulations has become a major concern due to their potential health risk. The study investigated the effect of class bitters(®) (CB) - a polyherbal formula prepared with Mondia whitei, Khaya senegalensis, Capparis erythrocarpus, Thoningia sanguinea and Xylopia aethiopica on serum electrolytes and hematological parameters in male Wistar albino rats. Two doses (500 and 1000 mg kg(–1)) of the polyherbal drugs were administered orally to male Wistar albino rats for a period of 9 weeks. The results showed that administration of 500 and 1000 mg kg(–1) body weight of CB recorded a marked increase in the levels of sodium and chlorum when compared with control. However, there was a marked reduction in the levels of potassium and hydrogen carbonate. The results of the study also showed a significant (P≤0.05) decrease in the level of hematological parameters such as hemoglobin (Hb), packed cell volume (PCV), red blood cells (RBCs) and platelets levels in the male Wistar albino rats, when compared with control. The marked decrease in Hb, PCV, RBCs and platelets concentrations observed in experimental rats in this study suggest that CB may have an adverse effect on erythropoiesis. These observations therefore showed that long-term administration of CB might cause renal disease and anemia. |
format | Online Article Text |
id | pubmed-6324464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-63244642019-01-30 Toxicity Effect of Sub-Chronic Oral Administration of Class Bitters® - A Polyherbal Formula on Serum Electrolytes and Hematological Indices in Male Wistar Albino Rats Patrick-Iwuanyanwu, Kingsley C. Nkpaa, Kpobari W. J Xenobiot Article The indiscriminate administration of ready-to-use herbal formulations has become a major concern due to their potential health risk. The study investigated the effect of class bitters(®) (CB) - a polyherbal formula prepared with Mondia whitei, Khaya senegalensis, Capparis erythrocarpus, Thoningia sanguinea and Xylopia aethiopica on serum electrolytes and hematological parameters in male Wistar albino rats. Two doses (500 and 1000 mg kg(–1)) of the polyherbal drugs were administered orally to male Wistar albino rats for a period of 9 weeks. The results showed that administration of 500 and 1000 mg kg(–1) body weight of CB recorded a marked increase in the levels of sodium and chlorum when compared with control. However, there was a marked reduction in the levels of potassium and hydrogen carbonate. The results of the study also showed a significant (P≤0.05) decrease in the level of hematological parameters such as hemoglobin (Hb), packed cell volume (PCV), red blood cells (RBCs) and platelets levels in the male Wistar albino rats, when compared with control. The marked decrease in Hb, PCV, RBCs and platelets concentrations observed in experimental rats in this study suggest that CB may have an adverse effect on erythropoiesis. These observations therefore showed that long-term administration of CB might cause renal disease and anemia. PAGEPress Publications, Pavia, Italy 2015-11-10 /pmc/articles/PMC6324464/ /pubmed/30701040 http://dx.doi.org/10.4081/xeno.2015.5369 Text en ©Copyright K.C. Patrick-Iwuanyanwu and K.W. Nkpaa http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Patrick-Iwuanyanwu, Kingsley C. Nkpaa, Kpobari W. Toxicity Effect of Sub-Chronic Oral Administration of Class Bitters® - A Polyherbal Formula on Serum Electrolytes and Hematological Indices in Male Wistar Albino Rats |
title | Toxicity Effect of Sub-Chronic Oral Administration of Class Bitters® - A Polyherbal Formula on Serum Electrolytes and Hematological Indices in Male Wistar Albino Rats |
title_full | Toxicity Effect of Sub-Chronic Oral Administration of Class Bitters® - A Polyherbal Formula on Serum Electrolytes and Hematological Indices in Male Wistar Albino Rats |
title_fullStr | Toxicity Effect of Sub-Chronic Oral Administration of Class Bitters® - A Polyherbal Formula on Serum Electrolytes and Hematological Indices in Male Wistar Albino Rats |
title_full_unstemmed | Toxicity Effect of Sub-Chronic Oral Administration of Class Bitters® - A Polyherbal Formula on Serum Electrolytes and Hematological Indices in Male Wistar Albino Rats |
title_short | Toxicity Effect of Sub-Chronic Oral Administration of Class Bitters® - A Polyherbal Formula on Serum Electrolytes and Hematological Indices in Male Wistar Albino Rats |
title_sort | toxicity effect of sub-chronic oral administration of class bitters® - a polyherbal formula on serum electrolytes and hematological indices in male wistar albino rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324464/ https://www.ncbi.nlm.nih.gov/pubmed/30701040 http://dx.doi.org/10.4081/xeno.2015.5369 |
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