The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of teste...

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Detalles Bibliográficos
Autores principales: Luterbach, Courtney L, Boshe, Ashley, Henderson, Heather I, Cober, Eric, Richter, Sandra S, Salata, Robert A, Kalayjian, Robert C, Watkins, Richard R, Hujer, Andrea M, Hujer, Kristine M, Rudin, Susan D, Domitrovic, T Nicholas, Doi, Yohei, Kaye, Keith S, Evans, Scott, Fowler, Vance G, Bonomo, Robert A, van Duin, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324543/
https://www.ncbi.nlm.nih.gov/pubmed/30631796
http://dx.doi.org/10.1093/ofid/ofy351
Descripción
Sumario:In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections.

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