Virological Failure in HIV to Triple Therapy With Dolutegravir-Based Firstline Treatment: Rare but Possible

We describe a case of virological failure during initial treatment with tenofovir disoproxil fumarate/emtricitabine/dolutegravir twice daily, with concomitant rifampin treatment of staphylococcal infection, selection of R263K + E157Q, and low plasma dolutegravir levels. Using rifampin together with...

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Detalles Bibliográficos
Autores principales: Pena, M J, Chueca, N, D’Avolio, A, Zarzalejos, J M, Garcia, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324549/
https://www.ncbi.nlm.nih.gov/pubmed/30631792
http://dx.doi.org/10.1093/ofid/ofy332
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author Pena, M J
Chueca, N
D’Avolio, A
Zarzalejos, J M
Garcia, F
author_facet Pena, M J
Chueca, N
D’Avolio, A
Zarzalejos, J M
Garcia, F
author_sort Pena, M J
collection PubMed
description We describe a case of virological failure during initial treatment with tenofovir disoproxil fumarate/emtricitabine/dolutegravir twice daily, with concomitant rifampin treatment of staphylococcal infection, selection of R263K + E157Q, and low plasma dolutegravir levels. Using rifampin together with dolutegravir may require closer follow-up, and, if possible, plasma dolutegravir levels should be monitored.
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spelling pubmed-63245492019-01-10 Virological Failure in HIV to Triple Therapy With Dolutegravir-Based Firstline Treatment: Rare but Possible Pena, M J Chueca, N D’Avolio, A Zarzalejos, J M Garcia, F Open Forum Infect Dis Brief Report We describe a case of virological failure during initial treatment with tenofovir disoproxil fumarate/emtricitabine/dolutegravir twice daily, with concomitant rifampin treatment of staphylococcal infection, selection of R263K + E157Q, and low plasma dolutegravir levels. Using rifampin together with dolutegravir may require closer follow-up, and, if possible, plasma dolutegravir levels should be monitored. Oxford University Press 2018-12-10 /pmc/articles/PMC6324549/ /pubmed/30631792 http://dx.doi.org/10.1093/ofid/ofy332 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Pena, M J
Chueca, N
D’Avolio, A
Zarzalejos, J M
Garcia, F
Virological Failure in HIV to Triple Therapy With Dolutegravir-Based Firstline Treatment: Rare but Possible
title Virological Failure in HIV to Triple Therapy With Dolutegravir-Based Firstline Treatment: Rare but Possible
title_full Virological Failure in HIV to Triple Therapy With Dolutegravir-Based Firstline Treatment: Rare but Possible
title_fullStr Virological Failure in HIV to Triple Therapy With Dolutegravir-Based Firstline Treatment: Rare but Possible
title_full_unstemmed Virological Failure in HIV to Triple Therapy With Dolutegravir-Based Firstline Treatment: Rare but Possible
title_short Virological Failure in HIV to Triple Therapy With Dolutegravir-Based Firstline Treatment: Rare but Possible
title_sort virological failure in hiv to triple therapy with dolutegravir-based firstline treatment: rare but possible
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324549/
https://www.ncbi.nlm.nih.gov/pubmed/30631792
http://dx.doi.org/10.1093/ofid/ofy332
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