TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle

A dominant histopathological feature in neuromuscular diseases including amyotrophic lateral sclerosis and inclusion body myopathy is cytoplasmic aggregation of the RNA-binding protein TDP-43. Although rare protein-misfolding mutations in TDP-43 often cause protein aggregation, most patients do not...

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Detalles Bibliográficos
Autores principales: Vogler, Thomas O., Wheeler, Joshua R., Nguyen, Eric D., Hughes, Michael P., Britson, Kyla A., Lester, Evan, Rao, Bhalchandra, Dalla Betta, Nicole, Whitney, Oscar N., Ewachiw, Theodore E., Gomes, Edward, Shorter, James, Lloyd, Thomas E., Eisenberg, David S., Taylor, J. Paul, Johnson, Aaron M., Olwin, Bradley B., Parker, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324568/
https://www.ncbi.nlm.nih.gov/pubmed/30464263
http://dx.doi.org/10.1038/s41586-018-0665-2

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