Payload of T-DM1 binds to cell surface cytoskeleton-associated protein 5 to mediate cytotoxicity of hepatocytes

Off-target toxicity is a major cause of dose-limiting toxicity for antibody-drug conjugates (ADCs), mechanisms of which remain poorly understood. Here, we demonstrate that cytoskeleton-associated protein 5 (CKAP5) serves as a cell surface target for T-DM1 and that binding of T-DM1 to CKAP5 is mediat...

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Detalles Bibliográficos
Autores principales: Endo, Yukinori, Takeda, Kazuyo, Mohan, Nishant, Shen, Yi, Jiang, Jiangsong, Rotstein, David, Wu, Wen Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324681/
https://www.ncbi.nlm.nih.gov/pubmed/30647854
http://dx.doi.org/10.18632/oncotarget.26461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324681/
https://www.ncbi.nlm.nih.gov/pubmed/30647854
http://dx.doi.org/10.18632/oncotarget.26461

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