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Microenvironment-derived ADAM28 prevents cancer dissemination
Previous studies have linked cancer cell-associated ADAM28 expression with tumor progression and metastatic dissemination. However, the role of host-derived ADAM28 in cancer dissemination processes remains unclear. Genetically engineered-mice fully deficient for ADAM28 unexpectedly display increased...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324684/ https://www.ncbi.nlm.nih.gov/pubmed/30647853 http://dx.doi.org/10.18632/oncotarget.26449 |
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author | Gérard, Catherine Hubeau, Céline Carnet, Oriane Bellefroid, Marine Sounni, Nor Eddine Blacher, Silvia Bendavid, Guillaume Moser, Markus Fässler, Reinhard Noel, Agnès Cataldo, Didier Rocks, Natacha |
author_facet | Gérard, Catherine Hubeau, Céline Carnet, Oriane Bellefroid, Marine Sounni, Nor Eddine Blacher, Silvia Bendavid, Guillaume Moser, Markus Fässler, Reinhard Noel, Agnès Cataldo, Didier Rocks, Natacha |
author_sort | Gérard, Catherine |
collection | PubMed |
description | Previous studies have linked cancer cell-associated ADAM28 expression with tumor progression and metastatic dissemination. However, the role of host-derived ADAM28 in cancer dissemination processes remains unclear. Genetically engineered-mice fully deficient for ADAM28 unexpectedly display increased lung colonization by pulmonary, melanoma or breast tumor cells. In experimental tumor cell dissemination models, host ADAM28 deficiency is further associated with a decreased lung infiltration by CD8(+) T lymphocytes. Notably, naive ADAM28-deficient mice already display a drastic reduction of CD8(+) T cells in spleen which is further observed in lungs. Interestingly, ex vivo CD8(+) T cell characterization revealed that ADAM28-deficiency does not impact proliferation, migration nor activation of CD8(+) T cells. Our data highlight a functional role of ADAM28 in T cell mobilization and point to an unexpected protective role for host ADAM28 against metastasis. |
format | Online Article Text |
id | pubmed-6324684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-63246842019-01-15 Microenvironment-derived ADAM28 prevents cancer dissemination Gérard, Catherine Hubeau, Céline Carnet, Oriane Bellefroid, Marine Sounni, Nor Eddine Blacher, Silvia Bendavid, Guillaume Moser, Markus Fässler, Reinhard Noel, Agnès Cataldo, Didier Rocks, Natacha Oncotarget Research Paper Previous studies have linked cancer cell-associated ADAM28 expression with tumor progression and metastatic dissemination. However, the role of host-derived ADAM28 in cancer dissemination processes remains unclear. Genetically engineered-mice fully deficient for ADAM28 unexpectedly display increased lung colonization by pulmonary, melanoma or breast tumor cells. In experimental tumor cell dissemination models, host ADAM28 deficiency is further associated with a decreased lung infiltration by CD8(+) T lymphocytes. Notably, naive ADAM28-deficient mice already display a drastic reduction of CD8(+) T cells in spleen which is further observed in lungs. Interestingly, ex vivo CD8(+) T cell characterization revealed that ADAM28-deficiency does not impact proliferation, migration nor activation of CD8(+) T cells. Our data highlight a functional role of ADAM28 in T cell mobilization and point to an unexpected protective role for host ADAM28 against metastasis. Impact Journals LLC 2018-12-14 /pmc/articles/PMC6324684/ /pubmed/30647853 http://dx.doi.org/10.18632/oncotarget.26449 Text en Copyright: © 2018 Gérard et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Gérard, Catherine Hubeau, Céline Carnet, Oriane Bellefroid, Marine Sounni, Nor Eddine Blacher, Silvia Bendavid, Guillaume Moser, Markus Fässler, Reinhard Noel, Agnès Cataldo, Didier Rocks, Natacha Microenvironment-derived ADAM28 prevents cancer dissemination |
title | Microenvironment-derived ADAM28 prevents cancer dissemination |
title_full | Microenvironment-derived ADAM28 prevents cancer dissemination |
title_fullStr | Microenvironment-derived ADAM28 prevents cancer dissemination |
title_full_unstemmed | Microenvironment-derived ADAM28 prevents cancer dissemination |
title_short | Microenvironment-derived ADAM28 prevents cancer dissemination |
title_sort | microenvironment-derived adam28 prevents cancer dissemination |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324684/ https://www.ncbi.nlm.nih.gov/pubmed/30647853 http://dx.doi.org/10.18632/oncotarget.26449 |
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