Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer

Claudin-4 (CLDN4) is a major epithelial tight junction protein overexpressed in many cancers to maintain the tumor environment. In this report, we aimed to determine the efficacy of targeting CLDN4 in colorectal cancer (CRC) using an anti-CLDN4 extracellular domain antibody, 4D3. CLDN4 was upregulat...

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Detalles Bibliográficos
Autores principales: Fujiwara-Tani, Rina, Sasaki, Takamitsu, Luo, Yi, Goto, Kei, Kawahara, Isao, Nishiguchi, Yukiko, Kishi, Shingo, Mori, Shiori, Ohmori, Hitoshi, Kondoh, Masuo, Kuniyasu, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324772/
https://www.ncbi.nlm.nih.gov/pubmed/30647838
http://dx.doi.org/10.18632/oncotarget.26427

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