Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling

Chromosome organization is crucial for genome function. Here, we present a method for visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce three-dimensional models of chromosome organization. Using the super-resolution microscopy methods of OligoSTORM and OligoDN...

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Detalles Bibliográficos
Autores principales: Nir, Guy, Farabella, Irene, Pérez Estrada, Cynthia, Ebeling, Carl G., Beliveau, Brian J., Sasaki, Hiroshi M., Lee, S. Dean, Nguyen, Son C., McCole, Ruth B., Chattoraj, Shyamtanu, Erceg, Jelena, AlHaj Abed, Jumana, Martins, Nuno M. C., Nguyen, Huy Q., Hannan, Mohammed A., Russell, Sheikh, Durand, Neva C., Rao, Suhas S. P., Kishi, Jocelyn Y., Soler-Vila, Paula, Di Pierro, Michele, Onuchic, José N., Callahan, Steven P., Schreiner, John M., Stuckey, Jeff A., Yin, Peng, Aiden, Erez Lieberman, Marti-Renom, Marc A., Wu, C.-ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324821/
https://www.ncbi.nlm.nih.gov/pubmed/30586358
http://dx.doi.org/10.1371/journal.pgen.1007872

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