Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

The recent successes of immunotherapy have shifted the paradigm in cancer treatment but since only a percentage of patients respond, it is imperative to identify factors impacting outcome. Obesity is reaching pandemic proportions and is a major risk factor for certain malignancies, but the impact of...

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Detalles Bibliográficos
Autores principales: Wang, Ziming, Aguilar, Ethan G., Luna, Jesus I., Dunai, Cordelia, Khuat, Lam T., Le, Catherine T., Mirsoian, Annie, Minnar, Christine M., Stoffel, Kevin M., Sturgill, Ian R., Grossenbacher, Steven K., Withers, Sita S., Rebhun, Robert B., Hartigan-O’Connor, Dennis J., Méndez-Lagares, Gema, Tarantal, Alice F., Isseroff, R. Rivkah, Griffith, Thomas S., Schalper, Kurt A., Merleev, Alexander, Saha, Asim, Maverakis, Emanual, Kelly, Karen, Aljumaily, Raid, Ibrahimi, Sami, Mukherjee, Sarbajit, Machiorlatti, Michael, Vesely, Sara K., Longo, Dan L., Blazar, Bruce R., Canter, Robert J., Murphy, William J., Monjazeb, Arta M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324991/
https://www.ncbi.nlm.nih.gov/pubmed/30420753
http://dx.doi.org/10.1038/s41591-018-0221-5

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