Azole resistance of Malassezia pachydermatis causing treatment failure in a dog

A 5-year-old neutered female toy Poodle chronically treated with systemic and topical azoles to control recurrent Malassezia dermatitis/otitis was presented because of the loss of treatment efficacy. Minimum Inhibitory Concentrations (MICs) obtained in vitro for various azoles (especially itraconazo...

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Detalles Bibliográficos
Autores principales: Angileri, Martina, Pasquetti, Mario, De Lucia, Michela, Peano, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325069/
https://www.ncbi.nlm.nih.gov/pubmed/30662826
http://dx.doi.org/10.1016/j.mmcr.2018.12.004
Descripción
Sumario:A 5-year-old neutered female toy Poodle chronically treated with systemic and topical azoles to control recurrent Malassezia dermatitis/otitis was presented because of the loss of treatment efficacy. Minimum Inhibitory Concentrations (MICs) obtained in vitro for various azoles (especially itraconazole and ketoconazole) against Malassezia strains isolated from the dog were increased by several-fold compared with MICs obtained for control isolates. These results reinforced the assumption based on clinical observation, i.e. the development of azole resistance

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