The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation

Protein-templated fragment ligations have been established as a powerful method for the assembly and detection of optimized protein ligands. Initially developed for reversible ligations, the method has been expanded to irreversible reactions enabling the formation of super-additive fragment combinat...

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Detalles Bibliográficos
Autores principales: Wong, Ee Lin, Nawrotzky, Eric, Arkona, Christoph, Kim, Boo Geun, Beligny, Samuel, Wang, Xinning, Wagner, Stefan, Lisurek, Michael, Carstanjen, Dirk, Rademann, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325109/
https://www.ncbi.nlm.nih.gov/pubmed/30622248
http://dx.doi.org/10.1038/s41467-018-07923-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325109/
https://www.ncbi.nlm.nih.gov/pubmed/30622248
http://dx.doi.org/10.1038/s41467-018-07923-2

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