The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis

Mitochondrial topoisomerase IB (TOP1MT) is a nuclear-encoded topoisomerase, exclusively localized to mitochondria, which resolves topological stress generated during mtDNA replication and transcription. Here, we report that TOP1MT is overexpressed in cancer tissues and demonstrate that TOP1MT defici...

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Detalles Bibliográficos
Autores principales: Baechler, S. A., Factor, V. M., Dalla Rosa, I., Ravji, A., Becker, D., Khiati, S., Miller Jenkins, L. M., Lang, M., Sourbier, C., Michaels, S. A., Neckers, L. M., Zhang, H. L., Spinazzola, A., Huang, S. N., Marquardt, J. U., Pommier, Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325124/
https://www.ncbi.nlm.nih.gov/pubmed/30622257
http://dx.doi.org/10.1038/s41467-018-07922-3

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