Genome-wide profiling of adenine base editor specificity by EndoV-seq

The adenine base editor (ABE), capable of catalyzing A•T to G•C conversions, is an important gene editing toolbox. Here, we systematically evaluate genome-wide off-target deamination by ABEs using the EndoV-seq platform we developed. EndoV-seq utilizes Endonuclease V to nick the inosine-containing D...

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Detalles Bibliográficos
Autores principales: Liang, Puping, Xie, Xiaowei, Zhi, Shengyao, Sun, Hongwei, Zhang, Xiya, Chen, Yu, Chen, Yuxi, Xiong, Yuanyan, Ma, Wenbin, Liu, Dan, Huang, Junjiu, Songyang, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325126/
https://www.ncbi.nlm.nih.gov/pubmed/30622278
http://dx.doi.org/10.1038/s41467-018-07988-z

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