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Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1

P-glycoprotein extrudes a large variety of xenobiotics from the cell, thereby protecting tissues from their toxic effects. The machinery underlying unidirectional multidrug pumping remains unknown, largely due to the lack of high-resolution structural information regarding the alternate conformation...

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Detalles Bibliográficos
Autores principales:	Kodan, Atsushi, Yamaguchi, Tomohiro, Nakatsu, Toru, Matsuoka, Keita, Kimura, Yasuhisa, Ueda, Kazumitsu, Kato, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325147/ https://www.ncbi.nlm.nih.gov/pubmed/30622258 http://dx.doi.org/10.1038/s41467-018-08007-x

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