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Activation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase

The diaminoquinazoline series has good potency against Mycobacterium tuberculosis. Resistant isolates have mutations in Rv3161c, a putative dioxygenase. We carried out metabolite analysis on a wild-type strain and an Rv3161c mutant strain after exposure to a diaminoquinazoline. The parental compound...

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Detalles Bibliográficos
Autores principales:	Melief, Eduard, Bonnett, Shilah A., Zuniga, Edison S., Parish, Tanya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325208/ https://www.ncbi.nlm.nih.gov/pubmed/30323042 http://dx.doi.org/10.1128/AAC.01505-18

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