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Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus

NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus particles with a mean antiviral 50% effective concentration (EC(50)) of 0.40 µM in H...

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Detalles Bibliográficos
Autores principales:	Lam, Angela M., Espiritu, Christine, Vogel, Robert, Ren, Suping, Lau, Vincent, Kelly, Mollie, Kuduk, Scott D., Hartman, George D., Flores, Osvaldo A., Klumpp, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325219/ https://www.ncbi.nlm.nih.gov/pubmed/30373799 http://dx.doi.org/10.1128/AAC.01734-18

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