Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Clostridium difficile Colitis while Dysregulating the Inflammatory Response

Clostridium difficile infection (CDI) is a major public health threat worldwide. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with enhanced susceptibility to and severity of CDI; however, the mechanisms driving this phenomenon have not been elucidated. NSAIDs alter prostagl...

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Detalles Bibliográficos
Autores principales: Maseda, Damian, Zackular, Joseph P., Trindade, Bruno, Kirk, Leslie, Roxas, Jennifer Lising, Rogers, Lisa M., Washington, Mary K., Du, Liping, Koyama, Tatsuki, Viswanathan, V. K., Vedantam, Gayatri, Schloss, Patrick D., Crofford, Leslie J., Skaar, Eric P., Aronoff, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325247/
https://www.ncbi.nlm.nih.gov/pubmed/30622186
http://dx.doi.org/10.1128/mBio.02282-18

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