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Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis

Upon invasion of Lewis rat macrophages, Toxoplasma rapidly induces programmed cell death (pyroptosis), which prevents Toxoplasma replication, possibly explaining the resistance of the Lewis rat to Toxoplasma. Using a chemical mutagenesis screen, we identified Toxoplasma mutants that no longer induce...

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Detalles Bibliográficos
Autores principales:	Wang, Yifan, Cirelli, Kimberly M., Barros, Patricio D. C., Sangaré, Lamba Omar, Butty, Vincent, Hassan, Musa A., Pesavento, Patricia, Mete, Asli, Saeij, Jeroen P. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325250/ https://www.ncbi.nlm.nih.gov/pubmed/30622189 http://dx.doi.org/10.1128/mBio.02388-18

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