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Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making

Decision making often requires weighing costs and benefits of different options that vary in terms of reward magnitude and uncertainty. Previous studies using pharmacological inactivations have shown that the basolateral amygdala (BLA) to nucleus accumbens (NAc) pathway promotes choice towards large...

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Autores principales: Bercovici, Debra A., Princz-Lebel, Oren, Tse, Maric T., Moorman, David E., Floresco, Stan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325538/
https://www.ncbi.nlm.nih.gov/pubmed/30627636
http://dx.doi.org/10.1523/ENEURO.0422-18.2018
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author Bercovici, Debra A.
Princz-Lebel, Oren
Tse, Maric T.
Moorman, David E.
Floresco, Stan B.
author_facet Bercovici, Debra A.
Princz-Lebel, Oren
Tse, Maric T.
Moorman, David E.
Floresco, Stan B.
author_sort Bercovici, Debra A.
collection PubMed
description Decision making often requires weighing costs and benefits of different options that vary in terms of reward magnitude and uncertainty. Previous studies using pharmacological inactivations have shown that the basolateral amygdala (BLA) to nucleus accumbens (NAc) pathway promotes choice towards larger/riskier rewards. Neural activity in BLA and NAc shows distinct, phasic changes in firing prior to choice and following action outcomes, yet, how these temporally-discrete patterns of activity within BLA→NAc circuitry influence choice is unclear. We assessed how optogenetic silencing of BLA terminals in the NAc altered action selection during probabilistic decision making. Rats received intra-BLA infusions of viruses encoding the inhibitory opsin eArchT and were well trained on a probabilistic discounting task, where they chose between smaller/certain rewards and larger rewards delivered in a probabilistic manner, with the odds of obtaining the larger reward changing over a session (50–12.5%). During testing, activity of BLA→NAc inputs were suppressed with 4- to 7-s pulses of light delivered via optic fibers into the NAc during discrete task events: prior to choice or after choice outcomes. Inhibition prior to choice reduced selection of the preferred option, suggesting that during deliberation, BLA→NAc activity biases choice towards preferred rewards. Inhibition during reward omissions increased risky choice during the low-probability block, indicating that activity after non-rewarded actions serves to modify subsequent choice. In contrast, silencing during rewarded outcomes did not reliably affect choice. These data demonstrate how patterns of activity in BLA→NAc circuitry convey different types of information that guide action selection in situations involving reward uncertainty.
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spelling pubmed-63255382019-01-09 Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making Bercovici, Debra A. Princz-Lebel, Oren Tse, Maric T. Moorman, David E. Floresco, Stan B. eNeuro New Research Decision making often requires weighing costs and benefits of different options that vary in terms of reward magnitude and uncertainty. Previous studies using pharmacological inactivations have shown that the basolateral amygdala (BLA) to nucleus accumbens (NAc) pathway promotes choice towards larger/riskier rewards. Neural activity in BLA and NAc shows distinct, phasic changes in firing prior to choice and following action outcomes, yet, how these temporally-discrete patterns of activity within BLA→NAc circuitry influence choice is unclear. We assessed how optogenetic silencing of BLA terminals in the NAc altered action selection during probabilistic decision making. Rats received intra-BLA infusions of viruses encoding the inhibitory opsin eArchT and were well trained on a probabilistic discounting task, where they chose between smaller/certain rewards and larger rewards delivered in a probabilistic manner, with the odds of obtaining the larger reward changing over a session (50–12.5%). During testing, activity of BLA→NAc inputs were suppressed with 4- to 7-s pulses of light delivered via optic fibers into the NAc during discrete task events: prior to choice or after choice outcomes. Inhibition prior to choice reduced selection of the preferred option, suggesting that during deliberation, BLA→NAc activity biases choice towards preferred rewards. Inhibition during reward omissions increased risky choice during the low-probability block, indicating that activity after non-rewarded actions serves to modify subsequent choice. In contrast, silencing during rewarded outcomes did not reliably affect choice. These data demonstrate how patterns of activity in BLA→NAc circuitry convey different types of information that guide action selection in situations involving reward uncertainty. Society for Neuroscience 2018-12-10 /pmc/articles/PMC6325538/ /pubmed/30627636 http://dx.doi.org/10.1523/ENEURO.0422-18.2018 Text en Copyright © 2018 Bercovici et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle New Research
Bercovici, Debra A.
Princz-Lebel, Oren
Tse, Maric T.
Moorman, David E.
Floresco, Stan B.
Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making
title Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making
title_full Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making
title_fullStr Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making
title_full_unstemmed Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making
title_short Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making
title_sort optogenetic dissection of temporal dynamics of amygdala-striatal interplay during risk/reward decision making
topic New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325538/
https://www.ncbi.nlm.nih.gov/pubmed/30627636
http://dx.doi.org/10.1523/ENEURO.0422-18.2018
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