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Long-Term Potentiation and Excitability in the Hippocampus Are Modulated Differently by θ Rhythm

Oscillations in the brain facilitate neural processing and cognitive functions. This study investigated the dependence of long-term potentiation (LTP), a neural correlate of memory, on the phase of the hippocampal θ rhythm, a prominent brain oscillation. Multichannel field potentials and current sou...

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Autores principales: Law, Clayton S. H., Leung, L. Stan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325566/
https://www.ncbi.nlm.nih.gov/pubmed/30627662
http://dx.doi.org/10.1523/ENEURO.0236-18.2018
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author Law, Clayton S. H.
Leung, L. Stan
author_facet Law, Clayton S. H.
Leung, L. Stan
author_sort Law, Clayton S. H.
collection PubMed
description Oscillations in the brain facilitate neural processing and cognitive functions. This study investigated the dependence of long-term potentiation (LTP), a neural correlate of memory, on the phase of the hippocampal θ rhythm, a prominent brain oscillation. Multichannel field potentials and current source-sinks were analyzed in hippocampal CA1 of adult male rats under urethane anesthesia. A single burst (five pulses at 200 Hz) stimulation of stratum oriens (OR) induced LTP of the basal dendritic excitatory sink (ES), which was maximal when the burst was delivered at ∼340° and ∼160° of the distal dendritic θ rhythm. Apical dendritic sink evoked by stratum radiatum (RAD) stimulation also showed biphasic maxima at ∼30° and ∼210° of the distal dendritic θ rhythm, about 50° phase delay to basal dendritic LTP. By contrast, maximal population spike (PS) excitability, following single-pulse excitation of the basal or mid-apical dendrites, occurred at a θ phase of ∼140°, and maximal basal dendritic ES occurred at ∼20°; γ (30–57 Hz) activity recorded in CA1 RAD had maximal power at ∼300° of the distal dendritic θ rhythm, different from the phases of maximal LTP. LTP induced during the rising θ phase was NMDA receptor sensitive. It is suggested that the θ phase modulation of CA1 PS excitability is mainly provided by θ-rhythmic proximal inhibition, while dendritic LTP is also modulated by dendritic inhibition and excitation, specific to basal and apical dendrites. In summary, basal and apical dendritic synaptic plasticity and spike excitability are facilitated at different θ phases in a compartmental fashion.
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spelling pubmed-63255662019-01-09 Long-Term Potentiation and Excitability in the Hippocampus Are Modulated Differently by θ Rhythm Law, Clayton S. H. Leung, L. Stan eNeuro Confirmation Oscillations in the brain facilitate neural processing and cognitive functions. This study investigated the dependence of long-term potentiation (LTP), a neural correlate of memory, on the phase of the hippocampal θ rhythm, a prominent brain oscillation. Multichannel field potentials and current source-sinks were analyzed in hippocampal CA1 of adult male rats under urethane anesthesia. A single burst (five pulses at 200 Hz) stimulation of stratum oriens (OR) induced LTP of the basal dendritic excitatory sink (ES), which was maximal when the burst was delivered at ∼340° and ∼160° of the distal dendritic θ rhythm. Apical dendritic sink evoked by stratum radiatum (RAD) stimulation also showed biphasic maxima at ∼30° and ∼210° of the distal dendritic θ rhythm, about 50° phase delay to basal dendritic LTP. By contrast, maximal population spike (PS) excitability, following single-pulse excitation of the basal or mid-apical dendrites, occurred at a θ phase of ∼140°, and maximal basal dendritic ES occurred at ∼20°; γ (30–57 Hz) activity recorded in CA1 RAD had maximal power at ∼300° of the distal dendritic θ rhythm, different from the phases of maximal LTP. LTP induced during the rising θ phase was NMDA receptor sensitive. It is suggested that the θ phase modulation of CA1 PS excitability is mainly provided by θ-rhythmic proximal inhibition, while dendritic LTP is also modulated by dendritic inhibition and excitation, specific to basal and apical dendrites. In summary, basal and apical dendritic synaptic plasticity and spike excitability are facilitated at different θ phases in a compartmental fashion. Society for Neuroscience 2018-11-22 /pmc/articles/PMC6325566/ /pubmed/30627662 http://dx.doi.org/10.1523/ENEURO.0236-18.2018 Text en Copyright © 2018 Law and Leung http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Confirmation
Law, Clayton S. H.
Leung, L. Stan
Long-Term Potentiation and Excitability in the Hippocampus Are Modulated Differently by θ Rhythm
title Long-Term Potentiation and Excitability in the Hippocampus Are Modulated Differently by θ Rhythm
title_full Long-Term Potentiation and Excitability in the Hippocampus Are Modulated Differently by θ Rhythm
title_fullStr Long-Term Potentiation and Excitability in the Hippocampus Are Modulated Differently by θ Rhythm
title_full_unstemmed Long-Term Potentiation and Excitability in the Hippocampus Are Modulated Differently by θ Rhythm
title_short Long-Term Potentiation and Excitability in the Hippocampus Are Modulated Differently by θ Rhythm
title_sort long-term potentiation and excitability in the hippocampus are modulated differently by θ rhythm
topic Confirmation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325566/
https://www.ncbi.nlm.nih.gov/pubmed/30627662
http://dx.doi.org/10.1523/ENEURO.0236-18.2018
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