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Ion Therapy: A Novel Strategy for Acute Myocardial Infarction

Although numerous therapies are widely applied clinically and stem cells and/or biomaterial based in situ implantations have achieved some effects, few of these have observed robust myocardial regeneration. The beneficial effects on cardiac function and structure are largely acting through paracrine...

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Detalles Bibliográficos
Autores principales: Yi, Min, Li, Hekai, Wang, Xiaoya, Yan, Jianyun, Gao, Long, He, Yinyan, Zhong, Xinglong, Cai, Yanbin, Feng, Weijing, Wen, Zhanpeng, Wu, Chengtie, Ou, Caiwen, Chang, Jiang, Chen, Minsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325593/
https://www.ncbi.nlm.nih.gov/pubmed/30643722
http://dx.doi.org/10.1002/advs.201801260
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author Yi, Min
Li, Hekai
Wang, Xiaoya
Yan, Jianyun
Gao, Long
He, Yinyan
Zhong, Xinglong
Cai, Yanbin
Feng, Weijing
Wen, Zhanpeng
Wu, Chengtie
Ou, Caiwen
Chang, Jiang
Chen, Minsheng
author_facet Yi, Min
Li, Hekai
Wang, Xiaoya
Yan, Jianyun
Gao, Long
He, Yinyan
Zhong, Xinglong
Cai, Yanbin
Feng, Weijing
Wen, Zhanpeng
Wu, Chengtie
Ou, Caiwen
Chang, Jiang
Chen, Minsheng
author_sort Yi, Min
collection PubMed
description Although numerous therapies are widely applied clinically and stem cells and/or biomaterial based in situ implantations have achieved some effects, few of these have observed robust myocardial regeneration. The beneficial effects on cardiac function and structure are largely acting through paracrine signaling, which preserve the border‐zone around the infarction, reduce apoptosis, blunt adverse remodeling, and promote angiogenesis. Ionic extracts from biomaterials have been proven to stimulate paracrine effects and promote cell–cell communications. Here, the paracrine stimulatory function of bioactive ions derived from biomaterials is integrated into the clinical concept of administration and proposed “ion therapy” as a novel strategy for myocardial infarction. In vitro, silicon‐ enriched ion extracts significantly increase cardiomyocyte viability and promote cell–cell communications, thus stimulating vascular formation via a paracrine effect under glucose/oxygen deprived conditions. In vivo, by intravenous injection, the bioactive silicon ions act as “diplomats” and promote crosstalk in myocardial cells, stimulate angiogenesis, and improve cardiac function post‐myocardial infarction.
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spelling pubmed-63255932019-01-14 Ion Therapy: A Novel Strategy for Acute Myocardial Infarction Yi, Min Li, Hekai Wang, Xiaoya Yan, Jianyun Gao, Long He, Yinyan Zhong, Xinglong Cai, Yanbin Feng, Weijing Wen, Zhanpeng Wu, Chengtie Ou, Caiwen Chang, Jiang Chen, Minsheng Adv Sci (Weinh) Full Papers Although numerous therapies are widely applied clinically and stem cells and/or biomaterial based in situ implantations have achieved some effects, few of these have observed robust myocardial regeneration. The beneficial effects on cardiac function and structure are largely acting through paracrine signaling, which preserve the border‐zone around the infarction, reduce apoptosis, blunt adverse remodeling, and promote angiogenesis. Ionic extracts from biomaterials have been proven to stimulate paracrine effects and promote cell–cell communications. Here, the paracrine stimulatory function of bioactive ions derived from biomaterials is integrated into the clinical concept of administration and proposed “ion therapy” as a novel strategy for myocardial infarction. In vitro, silicon‐ enriched ion extracts significantly increase cardiomyocyte viability and promote cell–cell communications, thus stimulating vascular formation via a paracrine effect under glucose/oxygen deprived conditions. In vivo, by intravenous injection, the bioactive silicon ions act as “diplomats” and promote crosstalk in myocardial cells, stimulate angiogenesis, and improve cardiac function post‐myocardial infarction. John Wiley and Sons Inc. 2018-11-08 /pmc/articles/PMC6325593/ /pubmed/30643722 http://dx.doi.org/10.1002/advs.201801260 Text en © 2018 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers
Yi, Min
Li, Hekai
Wang, Xiaoya
Yan, Jianyun
Gao, Long
He, Yinyan
Zhong, Xinglong
Cai, Yanbin
Feng, Weijing
Wen, Zhanpeng
Wu, Chengtie
Ou, Caiwen
Chang, Jiang
Chen, Minsheng
Ion Therapy: A Novel Strategy for Acute Myocardial Infarction
title Ion Therapy: A Novel Strategy for Acute Myocardial Infarction
title_full Ion Therapy: A Novel Strategy for Acute Myocardial Infarction
title_fullStr Ion Therapy: A Novel Strategy for Acute Myocardial Infarction
title_full_unstemmed Ion Therapy: A Novel Strategy for Acute Myocardial Infarction
title_short Ion Therapy: A Novel Strategy for Acute Myocardial Infarction
title_sort ion therapy: a novel strategy for acute myocardial infarction
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325593/
https://www.ncbi.nlm.nih.gov/pubmed/30643722
http://dx.doi.org/10.1002/advs.201801260
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