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Ion Therapy: A Novel Strategy for Acute Myocardial Infarction
Although numerous therapies are widely applied clinically and stem cells and/or biomaterial based in situ implantations have achieved some effects, few of these have observed robust myocardial regeneration. The beneficial effects on cardiac function and structure are largely acting through paracrine...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325593/ https://www.ncbi.nlm.nih.gov/pubmed/30643722 http://dx.doi.org/10.1002/advs.201801260 |
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author | Yi, Min Li, Hekai Wang, Xiaoya Yan, Jianyun Gao, Long He, Yinyan Zhong, Xinglong Cai, Yanbin Feng, Weijing Wen, Zhanpeng Wu, Chengtie Ou, Caiwen Chang, Jiang Chen, Minsheng |
author_facet | Yi, Min Li, Hekai Wang, Xiaoya Yan, Jianyun Gao, Long He, Yinyan Zhong, Xinglong Cai, Yanbin Feng, Weijing Wen, Zhanpeng Wu, Chengtie Ou, Caiwen Chang, Jiang Chen, Minsheng |
author_sort | Yi, Min |
collection | PubMed |
description | Although numerous therapies are widely applied clinically and stem cells and/or biomaterial based in situ implantations have achieved some effects, few of these have observed robust myocardial regeneration. The beneficial effects on cardiac function and structure are largely acting through paracrine signaling, which preserve the border‐zone around the infarction, reduce apoptosis, blunt adverse remodeling, and promote angiogenesis. Ionic extracts from biomaterials have been proven to stimulate paracrine effects and promote cell–cell communications. Here, the paracrine stimulatory function of bioactive ions derived from biomaterials is integrated into the clinical concept of administration and proposed “ion therapy” as a novel strategy for myocardial infarction. In vitro, silicon‐ enriched ion extracts significantly increase cardiomyocyte viability and promote cell–cell communications, thus stimulating vascular formation via a paracrine effect under glucose/oxygen deprived conditions. In vivo, by intravenous injection, the bioactive silicon ions act as “diplomats” and promote crosstalk in myocardial cells, stimulate angiogenesis, and improve cardiac function post‐myocardial infarction. |
format | Online Article Text |
id | pubmed-6325593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63255932019-01-14 Ion Therapy: A Novel Strategy for Acute Myocardial Infarction Yi, Min Li, Hekai Wang, Xiaoya Yan, Jianyun Gao, Long He, Yinyan Zhong, Xinglong Cai, Yanbin Feng, Weijing Wen, Zhanpeng Wu, Chengtie Ou, Caiwen Chang, Jiang Chen, Minsheng Adv Sci (Weinh) Full Papers Although numerous therapies are widely applied clinically and stem cells and/or biomaterial based in situ implantations have achieved some effects, few of these have observed robust myocardial regeneration. The beneficial effects on cardiac function and structure are largely acting through paracrine signaling, which preserve the border‐zone around the infarction, reduce apoptosis, blunt adverse remodeling, and promote angiogenesis. Ionic extracts from biomaterials have been proven to stimulate paracrine effects and promote cell–cell communications. Here, the paracrine stimulatory function of bioactive ions derived from biomaterials is integrated into the clinical concept of administration and proposed “ion therapy” as a novel strategy for myocardial infarction. In vitro, silicon‐ enriched ion extracts significantly increase cardiomyocyte viability and promote cell–cell communications, thus stimulating vascular formation via a paracrine effect under glucose/oxygen deprived conditions. In vivo, by intravenous injection, the bioactive silicon ions act as “diplomats” and promote crosstalk in myocardial cells, stimulate angiogenesis, and improve cardiac function post‐myocardial infarction. John Wiley and Sons Inc. 2018-11-08 /pmc/articles/PMC6325593/ /pubmed/30643722 http://dx.doi.org/10.1002/advs.201801260 Text en © 2018 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Papers Yi, Min Li, Hekai Wang, Xiaoya Yan, Jianyun Gao, Long He, Yinyan Zhong, Xinglong Cai, Yanbin Feng, Weijing Wen, Zhanpeng Wu, Chengtie Ou, Caiwen Chang, Jiang Chen, Minsheng Ion Therapy: A Novel Strategy for Acute Myocardial Infarction |
title | Ion Therapy: A Novel Strategy for Acute Myocardial Infarction |
title_full | Ion Therapy: A Novel Strategy for Acute Myocardial Infarction |
title_fullStr | Ion Therapy: A Novel Strategy for Acute Myocardial Infarction |
title_full_unstemmed | Ion Therapy: A Novel Strategy for Acute Myocardial Infarction |
title_short | Ion Therapy: A Novel Strategy for Acute Myocardial Infarction |
title_sort | ion therapy: a novel strategy for acute myocardial infarction |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325593/ https://www.ncbi.nlm.nih.gov/pubmed/30643722 http://dx.doi.org/10.1002/advs.201801260 |
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