Cargando…

Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study

Acellular human dermal allografts have been shown to be effective for soft-tissue implantation. We compared treatment outcomes of tympanoplasty using tragal perichondrium and acellular human dermal allograft (MegaDerm(®)). In a prospective randomised controlled study, 60 patients scheduled to underg...

Descripción completa

Detalles Bibliográficos
Autores principales: LEE, J.M., SEO, Y.J., SHIM, D.B., LEE, H.J., KIM, S.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore Srl 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325656/
https://www.ncbi.nlm.nih.gov/pubmed/30623901
http://dx.doi.org/10.14639/0392-100X-1839
_version_ 1783386160712646656
author LEE, J.M.
SEO, Y.J.
SHIM, D.B.
LEE, H.J.
KIM, S.H.
author_facet LEE, J.M.
SEO, Y.J.
SHIM, D.B.
LEE, H.J.
KIM, S.H.
author_sort LEE, J.M.
collection PubMed
description Acellular human dermal allografts have been shown to be effective for soft-tissue implantation. We compared treatment outcomes of tympanoplasty using tragal perichondrium and acellular human dermal allograft (MegaDerm(®)). In a prospective randomised controlled study, 60 patients scheduled to undergo tympanoplasty were randomly assigned to the autologous tragal perichondrium group (n = 33) or acellular human dermal allograft group (n = 27). Postoperative hearing gain, graft success rate at 1 and 6 months and operation times were compared between groups. Graft success rate, defined as the complete closure of tympanic membrane perforation, did not show any significant intergroup difference (75.8% vs 85.2%, p = 0.519). Air conduction thresholds and air-bone gaps showed significant improvements in both groups; from 38.7 ± 15.9 dB to 30.2 ± 15.6 dB (p < 0.001) and from 17.8 ± 7.3 dB to 11.5 ± 7.0 (p = 0.001) in the autologous tragal perichondrium group, and from 30.4 ± 12.2 dB to 24.5 ± 13.0 dB (p = 0.006) and from 14.3 ± 5.1 dB to 7.6 ± 4.6 dB (p < 0.001) in the acellular human dermal allograft group. The amount of hearing gain (p = 0.31) and closure of air-bone gap (p = 0.863) were not meaningfully different between groups. The mean operation time was significantly lower in the acellular human dermal allograft group (35.2 min vs 27.4 min, p = 0.039). In this prospective randomised controlled study, acellular human dermal allograft was shown to be an effective alternative to tragal perichondrium, with similar graft success rates and postoperative hearing results, but with reduced operation times.
format Online
Article
Text
id pubmed-6325656
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Pacini Editore Srl
record_format MEDLINE/PubMed
spelling pubmed-63256562019-01-18 Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study LEE, J.M. SEO, Y.J. SHIM, D.B. LEE, H.J. KIM, S.H. Acta Otorhinolaryngol Ital Otology Acellular human dermal allografts have been shown to be effective for soft-tissue implantation. We compared treatment outcomes of tympanoplasty using tragal perichondrium and acellular human dermal allograft (MegaDerm(®)). In a prospective randomised controlled study, 60 patients scheduled to undergo tympanoplasty were randomly assigned to the autologous tragal perichondrium group (n = 33) or acellular human dermal allograft group (n = 27). Postoperative hearing gain, graft success rate at 1 and 6 months and operation times were compared between groups. Graft success rate, defined as the complete closure of tympanic membrane perforation, did not show any significant intergroup difference (75.8% vs 85.2%, p = 0.519). Air conduction thresholds and air-bone gaps showed significant improvements in both groups; from 38.7 ± 15.9 dB to 30.2 ± 15.6 dB (p < 0.001) and from 17.8 ± 7.3 dB to 11.5 ± 7.0 (p = 0.001) in the autologous tragal perichondrium group, and from 30.4 ± 12.2 dB to 24.5 ± 13.0 dB (p = 0.006) and from 14.3 ± 5.1 dB to 7.6 ± 4.6 dB (p < 0.001) in the acellular human dermal allograft group. The amount of hearing gain (p = 0.31) and closure of air-bone gap (p = 0.863) were not meaningfully different between groups. The mean operation time was significantly lower in the acellular human dermal allograft group (35.2 min vs 27.4 min, p = 0.039). In this prospective randomised controlled study, acellular human dermal allograft was shown to be an effective alternative to tragal perichondrium, with similar graft success rates and postoperative hearing results, but with reduced operation times. Pacini Editore Srl 2018-12 /pmc/articles/PMC6325656/ /pubmed/30623901 http://dx.doi.org/10.14639/0392-100X-1839 Text en Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale, Rome, Italy http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. For details, please refer to https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Otology
LEE, J.M.
SEO, Y.J.
SHIM, D.B.
LEE, H.J.
KIM, S.H.
Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study
title Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study
title_full Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study
title_fullStr Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study
title_full_unstemmed Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study
title_short Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study
title_sort surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study
topic Otology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325656/
https://www.ncbi.nlm.nih.gov/pubmed/30623901
http://dx.doi.org/10.14639/0392-100X-1839
work_keys_str_mv AT leejm surgicaloutcomesoftympanoplastyusingasterileacellulardermalallograftaprospectiverandomisedcontrolledstudy
AT seoyj surgicaloutcomesoftympanoplastyusingasterileacellulardermalallograftaprospectiverandomisedcontrolledstudy
AT shimdb surgicaloutcomesoftympanoplastyusingasterileacellulardermalallograftaprospectiverandomisedcontrolledstudy
AT leehj surgicaloutcomesoftympanoplastyusingasterileacellulardermalallograftaprospectiverandomisedcontrolledstudy
AT kimsh surgicaloutcomesoftympanoplastyusingasterileacellulardermalallograftaprospectiverandomisedcontrolledstudy