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Terlipressin-Induced Peripheral Cyanosis in a Patient with Liver Cirrhosis and Hepatorenal Syndrome
Patient: Male, 65 Final Diagnosis: Terlipressin-induced peripheral cyanosis Symptoms: Cold extremities Medication: Terlipressin Clinical Procedure: Terlipressin administration was discontinued Specialty: Gastroenterology and Hepatology OBJECTIVE: Challenging differential diagnosis BACKGROUND: Hepato...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325660/ https://www.ncbi.nlm.nih.gov/pubmed/30600312 http://dx.doi.org/10.12659/AJCR.913150 |
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author | Chiang, Chi-Wen Lin, Yun-Ju Huang, Yaw-Bin |
author_facet | Chiang, Chi-Wen Lin, Yun-Ju Huang, Yaw-Bin |
author_sort | Chiang, Chi-Wen |
collection | PubMed |
description | Patient: Male, 65 Final Diagnosis: Terlipressin-induced peripheral cyanosis Symptoms: Cold extremities Medication: Terlipressin Clinical Procedure: Terlipressin administration was discontinued Specialty: Gastroenterology and Hepatology OBJECTIVE: Challenging differential diagnosis BACKGROUND: Hepatorenal syndrome (HRS), which is a type of functional renal impairment, is one of the most serious complications in patients with liver cirrhosis. Terlipressin can induce splanchnic vasoconstriction, which increases the renal blood flow and has beneficial effects on HRS. However, terlipressin administration may cause serious ischemic complications such as skin ischemia, peripheral gangrene, and ischemic bowel necrosis. Here, we report a case of peripheral cyanosis following terlipressin administration in a cirrhotic patient with HRS. CASE REPORT: The patient was a 65-year-old male. He was considered to have type-1 HRS, and thus, terlipressin was administered. However, peripheral cyanosis involving the fingers, toes, area around an umbilical hernia, and scrotum was noted. Thus, terlipressin administration was discontinued. Subsequently, his condition rapidly improved. CONCLUSIONS: We reported a case of peripheral cyanosis following terlipressin administration, which resolved after discontinuation of terlipressin administration. It is important to recognize the early signs of side effects and discontinue the administration of the suspected drug immediately. |
format | Online Article Text |
id | pubmed-6325660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63256602019-01-25 Terlipressin-Induced Peripheral Cyanosis in a Patient with Liver Cirrhosis and Hepatorenal Syndrome Chiang, Chi-Wen Lin, Yun-Ju Huang, Yaw-Bin Am J Case Rep Articles Patient: Male, 65 Final Diagnosis: Terlipressin-induced peripheral cyanosis Symptoms: Cold extremities Medication: Terlipressin Clinical Procedure: Terlipressin administration was discontinued Specialty: Gastroenterology and Hepatology OBJECTIVE: Challenging differential diagnosis BACKGROUND: Hepatorenal syndrome (HRS), which is a type of functional renal impairment, is one of the most serious complications in patients with liver cirrhosis. Terlipressin can induce splanchnic vasoconstriction, which increases the renal blood flow and has beneficial effects on HRS. However, terlipressin administration may cause serious ischemic complications such as skin ischemia, peripheral gangrene, and ischemic bowel necrosis. Here, we report a case of peripheral cyanosis following terlipressin administration in a cirrhotic patient with HRS. CASE REPORT: The patient was a 65-year-old male. He was considered to have type-1 HRS, and thus, terlipressin was administered. However, peripheral cyanosis involving the fingers, toes, area around an umbilical hernia, and scrotum was noted. Thus, terlipressin administration was discontinued. Subsequently, his condition rapidly improved. CONCLUSIONS: We reported a case of peripheral cyanosis following terlipressin administration, which resolved after discontinuation of terlipressin administration. It is important to recognize the early signs of side effects and discontinue the administration of the suspected drug immediately. International Scientific Literature, Inc. 2019-01-02 /pmc/articles/PMC6325660/ /pubmed/30600312 http://dx.doi.org/10.12659/AJCR.913150 Text en © Am J Case Rep, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Chiang, Chi-Wen Lin, Yun-Ju Huang, Yaw-Bin Terlipressin-Induced Peripheral Cyanosis in a Patient with Liver Cirrhosis and Hepatorenal Syndrome |
title | Terlipressin-Induced Peripheral Cyanosis in a Patient with Liver Cirrhosis and Hepatorenal Syndrome |
title_full | Terlipressin-Induced Peripheral Cyanosis in a Patient with Liver Cirrhosis and Hepatorenal Syndrome |
title_fullStr | Terlipressin-Induced Peripheral Cyanosis in a Patient with Liver Cirrhosis and Hepatorenal Syndrome |
title_full_unstemmed | Terlipressin-Induced Peripheral Cyanosis in a Patient with Liver Cirrhosis and Hepatorenal Syndrome |
title_short | Terlipressin-Induced Peripheral Cyanosis in a Patient with Liver Cirrhosis and Hepatorenal Syndrome |
title_sort | terlipressin-induced peripheral cyanosis in a patient with liver cirrhosis and hepatorenal syndrome |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325660/ https://www.ncbi.nlm.nih.gov/pubmed/30600312 http://dx.doi.org/10.12659/AJCR.913150 |
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