Cargando…
Very low-level prenatal mercury exposure and behaviors in children: the HOME Study
BACKGROUND: Mercury is toxic to the developing brain, but the lowest concentration associated with the development of behavior problems is unclear. The purpose of this study was to examine the association between very low-level mercury exposure during fetal development and behavior problems in child...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325670/ https://www.ncbi.nlm.nih.gov/pubmed/30626382 http://dx.doi.org/10.1186/s12940-018-0443-5 |
_version_ | 1783386164102692864 |
---|---|
author | Patel, Nimesh B. Xu, Yingying McCandless, Lawrence C. Chen, Aimin Yolton, Kimberly Braun, Joseph Jones, Robert L. Dietrich, Kim N. Lanphear, Bruce P. |
author_facet | Patel, Nimesh B. Xu, Yingying McCandless, Lawrence C. Chen, Aimin Yolton, Kimberly Braun, Joseph Jones, Robert L. Dietrich, Kim N. Lanphear, Bruce P. |
author_sort | Patel, Nimesh B. |
collection | PubMed |
description | BACKGROUND: Mercury is toxic to the developing brain, but the lowest concentration associated with the development of behavior problems is unclear. The purpose of this study was to examine the association between very low-level mercury exposure during fetal development and behavior problems in children. METHODS: We used data from 389 mothers and children in a prospective pregnancy and birth cohort study. We defined mean prenatal mercury concentration as the mean of total whole blood mercury concentrations in maternal samples collected at 16- and 26-weeks of gestation, delivery, and neonatal cord blood samples. We assessed parent-reported child behavior up to five times from two to 8 years of age using the Behavioral Assessment System for Children (BASC-2). At 8 years of age, we assessed self-reported child anxiety using the Spence Children’s Anxiety Scale (SCAS). We used multiple linear mixed models and linear regression models to estimate the association between mean prenatal mercury concentrations and child behavior and anxiety, respectively. RESULTS: The median prenatal total blood mercury concentrations was 0.67 μg/L. Overall, we did not find statistically significant associations between mean prenatal mercury concentrations and behavior problems scores, but a 2-fold increase in mercury concentrations at 16-weeks gestation was associated with 0.83 point (95% CI: 0.05, 1.62) higher BASC-2 anxiety scores. Maternal and cord blood mercury concentrations at delivery were associated with parent-reported anxiety at 8 years. CONCLUSION: We found limited evidence of an association between very-low level prenatal mercury exposure and behaviors in children, with an exception of anxiety. |
format | Online Article Text |
id | pubmed-6325670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63256702019-01-11 Very low-level prenatal mercury exposure and behaviors in children: the HOME Study Patel, Nimesh B. Xu, Yingying McCandless, Lawrence C. Chen, Aimin Yolton, Kimberly Braun, Joseph Jones, Robert L. Dietrich, Kim N. Lanphear, Bruce P. Environ Health Research BACKGROUND: Mercury is toxic to the developing brain, but the lowest concentration associated with the development of behavior problems is unclear. The purpose of this study was to examine the association between very low-level mercury exposure during fetal development and behavior problems in children. METHODS: We used data from 389 mothers and children in a prospective pregnancy and birth cohort study. We defined mean prenatal mercury concentration as the mean of total whole blood mercury concentrations in maternal samples collected at 16- and 26-weeks of gestation, delivery, and neonatal cord blood samples. We assessed parent-reported child behavior up to five times from two to 8 years of age using the Behavioral Assessment System for Children (BASC-2). At 8 years of age, we assessed self-reported child anxiety using the Spence Children’s Anxiety Scale (SCAS). We used multiple linear mixed models and linear regression models to estimate the association between mean prenatal mercury concentrations and child behavior and anxiety, respectively. RESULTS: The median prenatal total blood mercury concentrations was 0.67 μg/L. Overall, we did not find statistically significant associations between mean prenatal mercury concentrations and behavior problems scores, but a 2-fold increase in mercury concentrations at 16-weeks gestation was associated with 0.83 point (95% CI: 0.05, 1.62) higher BASC-2 anxiety scores. Maternal and cord blood mercury concentrations at delivery were associated with parent-reported anxiety at 8 years. CONCLUSION: We found limited evidence of an association between very-low level prenatal mercury exposure and behaviors in children, with an exception of anxiety. BioMed Central 2019-01-09 /pmc/articles/PMC6325670/ /pubmed/30626382 http://dx.doi.org/10.1186/s12940-018-0443-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Patel, Nimesh B. Xu, Yingying McCandless, Lawrence C. Chen, Aimin Yolton, Kimberly Braun, Joseph Jones, Robert L. Dietrich, Kim N. Lanphear, Bruce P. Very low-level prenatal mercury exposure and behaviors in children: the HOME Study |
title | Very low-level prenatal mercury exposure and behaviors in children: the HOME Study |
title_full | Very low-level prenatal mercury exposure and behaviors in children: the HOME Study |
title_fullStr | Very low-level prenatal mercury exposure and behaviors in children: the HOME Study |
title_full_unstemmed | Very low-level prenatal mercury exposure and behaviors in children: the HOME Study |
title_short | Very low-level prenatal mercury exposure and behaviors in children: the HOME Study |
title_sort | very low-level prenatal mercury exposure and behaviors in children: the home study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325670/ https://www.ncbi.nlm.nih.gov/pubmed/30626382 http://dx.doi.org/10.1186/s12940-018-0443-5 |
work_keys_str_mv | AT patelnimeshb verylowlevelprenatalmercuryexposureandbehaviorsinchildrenthehomestudy AT xuyingying verylowlevelprenatalmercuryexposureandbehaviorsinchildrenthehomestudy AT mccandlesslawrencec verylowlevelprenatalmercuryexposureandbehaviorsinchildrenthehomestudy AT chenaimin verylowlevelprenatalmercuryexposureandbehaviorsinchildrenthehomestudy AT yoltonkimberly verylowlevelprenatalmercuryexposureandbehaviorsinchildrenthehomestudy AT braunjoseph verylowlevelprenatalmercuryexposureandbehaviorsinchildrenthehomestudy AT jonesrobertl verylowlevelprenatalmercuryexposureandbehaviorsinchildrenthehomestudy AT dietrichkimn verylowlevelprenatalmercuryexposureandbehaviorsinchildrenthehomestudy AT lanphearbrucep verylowlevelprenatalmercuryexposureandbehaviorsinchildrenthehomestudy |