Cargando…

A rare population of tumor antigen-specific CD4(+)CD8(+) double-positive αβ T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells

BACKGROUND: High-affinity tumor antigen-specific T-cell receptor (TCR) gene is required to engineer potent T cells for therapeutic treatment of cancer patients. However, discovery of suitable therapeutic TCR genes is hampered by the fact that naturally occurring tumor antigen-specific TCRs are gener...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matsuzaki, Junko, Tsuji, Takemasa, Chodon, Thinle, Ryan, Courtney, Koya, Richard C., Odunsi, Kunle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325755/ https://www.ncbi.nlm.nih.gov/pubmed/30626427 http://dx.doi.org/10.1186/s40425-018-0467-y

Ejemplares similares

Tcf-1 protects anti-tumor TCR-engineered CD8(+) T-cells from GzmB mediated self-destruction
por: Zangari, Brendan, et al.
Publicado: (2022)

Correction to: Tcf‑1 protects anti‑tumor TCR‑engineered CD8(+) T‑cells from GzmB mediated self‑destruction
por: Zangari, Brendan, et al.
Publicado: (2022)

CXCR6 by increasing retention of memory CD8(+) T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer
por: Muthuswamy, Ravikumar, et al.
Publicado: (2021)

Split T Cell Tolerance against a Self/Tumor Antigen: Spontaneous CD4(+) but Not CD8(+) T Cell Responses against p53 in Cancer Patients and Healthy Donors
por: Tsuji, Takemasa, et al.
Publicado: (2011)

Identification and Regulation of TCRαβ(+)CD8αα(+) Intraepithelial Lymphocytes in Murine Oral Mucosa
por: Wu, Ruiqing, et al.
Publicado: (2020)

The Molecular Signature Underlying the Thymic Migration and Maturation of TCRαβ(+)CD4(+)CD8(-) Thymocytes
por: Teng, Fei, et al.
Publicado: (2011)

Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ((+))CD8αα((+)) intraepithelial lymphocytes
por: Grandjean, Capucine L., et al.
Publicado: (2017)

Non-canonicaly recruited TCRαβCD8αα IELs recognize microbial antigens
por: Wojciech, Lukasz, et al.
Publicado: (2018)

Distinct Features of Canine Non-conventional CD4(−)CD8α(−) Double-Negative TCRαβ(+) vs. TCRγδ(+) T Cells
por: Rabiger, Friederike V., et al.
Publicado: (2019)

Thymic progenitors of TCRαβ(+) CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development
por: Golec, Dominic P., et al.
Publicado: (2017)

Lack of common TCRA and TCRB clonotypes in CD8(+)/TCRαβ(+) T-cell large granular lymphocyte leukemia: a review on the role of antigenic selection in the immunopathogenesis of CD8(+) T-LGL
por: Sandberg, Y, et al.
Publicado: (2014)

The Eδ enhancer controls the generation of CD4(−)CD8(−) αβTCR-expressing T cells that can give rise to different lineages of αβ T cells
por: Aifantis, Iannis, et al.
Publicado: (2006)

Maintenance of the EBV-specific CD8(+) TCRαβ repertoire in immunosuppressed lung transplant recipients
por: Nguyen, Thi HO, et al.
Publicado: (2017)

Rapid Generation of TCR and CD8αβ Transgenic Virus Specific T Cells for Immunotherapy of Leukemia
por: Bajwa, Gagan, et al.
Publicado: (2022)

Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells
por: Bajwa, Gagan, et al.
Publicado: (2020)

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy
por: Komdeur, Fenne L., et al.
Publicado: (2016)

The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ(+)CD8αα(+) intestinal intraepithelial lymphocytes
por: Zhang, Haohao, et al.
Publicado: (2022)

Erratum: Rapid generation of TCR and CD8αβ transgenic virus specific T cells for immunotherapy of leukemia
Publicado: (2023)

Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period
por: Torow, Natalia, et al.
Publicado: (2015)

Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4(+) T cells
por: Rath, Jan A., et al.
Publicado: (2020)

CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRαβ Complex
por: Garcillán, Beatriz, et al.
Publicado: (2021)

Early expression of mature αβ TCR in CD4(−)CD8(−) T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations
por: Laffey, Kimberly G., et al.
Publicado: (2022)

CD3+CD16+NK1.1+B220+ large granular lymphocytes arise from both alpha- beta TCR+CD4-CD8- and gamma-delta TCR+CD4-CD8- cells
Publicado: (1994)

Development and function of natural TCR(+) CD8αα(+) intraepithelial lymphocytes
por: Gui, Yuanyuan, et al.
Publicado: (2022)

Contrasted TCRβ Diversity of CD8(+) and CD8(−) T Cells in Rainbow Trout
por: Castro, Rosario, et al.
Publicado: (2013)

TCRαβ(+)NK1.1(-)CD4(-)CD8(-) double-negative T cells inhibit central and peripheral inflammation and ameliorate ischemic stroke in mice
por: Tian, Dan, et al.
Publicado: (2023)

LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8(+) T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
por: Huang, Ruea-Yea, et al.
Publicado: (2015)

miR-181a is a novel player in the STAT3-mediated survival network of TCRαβ+ CD8+ T large granular lymphocyte leukemia
por: Assmann, Jorn L. J. C., et al.
Publicado: (2021)

Identification of Claudin 6-specific HLA class I- and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancer
por: Matsuzaki, Junko, et al.
Publicado: (2022)

CD8β Increases CD8 Coreceptor Function and Participation in TCR–Ligand Binding
por: Renard, Valery, et al.
Publicado: (1996)

Genetic engineering of T cells with receptors from NY-ESO-1-specific tumor-recognizing CD4+ T cell as a novel approach for adoptive T cell therapy
por: Matsuzaki, Junko, et al.
Publicado: (2015)

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ(+)CD8αα(+) T cells
por: Ishifune, Chieko, et al.
Publicado: (2019)

Recovery from Mouse Hepatitis Virus Infection Depends on Recruitment of CD8(+) Cells Rather Than Activation of Intrahepatic CD4(+)αβ(−)TCR(inter) or NK-T Cells
por: Lamontagne, Lucie, et al.
Publicado: (2001)

Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
por: Duong, Minh Ngoc, et al.
Publicado: (2019)

Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses
por: Matsuzaki, Junko, et al.
Publicado: (2015)

Streptococcus pneumoniae Serotype 1 Capsular Polysaccharide Induces CD8(+)CD28(−) Regulatory T Lymphocytes by TCR Crosslinking
por: Mertens, Janina, et al.
Publicado: (2009)

Lymph node γδ and αβ CD8(+) T cells share migratory properties
por: Ugur, Milas, et al.
Publicado: (2018)

CD4-CD8-αβ and γδ T Cells Display Inflammatory and Regulatory Potentials during Human Tuberculosis
por: Pinheiro, Melina B., et al.
Publicado: (2012)

Clonal dynamics underlying the skewed CD4/CD8 ratio of mouse thymocytes revealed by TCR-independent barcoding
por: Iwanami, Norimasa, et al.
Publicado: (2022)

The thymoproteasome hardwires the TCR repertoire of CD8(+) T cells in the cortex independent of negative selection
por: Ohigashi, Izumi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_09s4l4p4634f3rgm7ula5igcfi