Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis

BACKGROUND: Multiple myeloma (MM) is a clonal plasma cell malignancy associated with osteolytic bone disease. Recently, the role of MM-derived exosomes in the osteoclastogenesis has been demonstrated although the underlying mechanism is still unknown. Since exosomes-derived epidermal growth factor r...

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Detalles Bibliográficos
Autores principales: Raimondo, Stefania, Saieva, Laura, Vicario, Emanuela, Pucci, Marzia, Toscani, Denise, Manno, Mauro, Raccosta, Samuele, Giuliani, Nicola, Alessandro, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325886/
https://www.ncbi.nlm.nih.gov/pubmed/30621731
http://dx.doi.org/10.1186/s13045-018-0689-y

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