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Pharmacokinetics and Pharmacodynamics of Once-Weekly Somapacitan in Children and Adults: Supporting Dosing Rationales with a Model-Based Analysis of Three Phase I Trials

BACKGROUND: Somapacitan, a long-acting growth hormone (GH) derivative, has been well-tolerated in children with GH deficiency (GHD) and adults (healthy and adult GHD), in phase I, single- and multiple-dose trials, respectively, and has pharmacokinetic and pharmacodynamic properties supporting a once...

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Detalles Bibliográficos
Autores principales:	Juul, Rasmus Vestergaard, Rasmussen, Michael Højby, Agersø, Henrik, Overgaard, Rune Viig
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2018
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325982/ https://www.ncbi.nlm.nih.gov/pubmed/29671202 http://dx.doi.org/10.1007/s40262-018-0662-5

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