Pharmacokinetic–Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance

Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and conduct of clinical pharmacology research in children. During drug development, PKPD modeling and simulation should underpin rational trial design and facilitate extrapolation to investigate efficacy and safety. The appli...

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Detalles Bibliográficos
Autores principales: Germovsek, Eva, Barker, Charlotte I. S., Sharland, Mike, Standing, Joseph F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325987/
https://www.ncbi.nlm.nih.gov/pubmed/29675639
http://dx.doi.org/10.1007/s40262-018-0659-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325987/
https://www.ncbi.nlm.nih.gov/pubmed/29675639
http://dx.doi.org/10.1007/s40262-018-0659-0

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