Cargando…

Short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life

PURPOSE: Head and neck cancer treatment achieves good locoregional tumor control rates while causing severe side effects. Therapy with chemotherapeutic drugs administered intravenously is limited because either the concentrations at the tumor site are too low or the total dosages are too high. The e...

Descripción completa

Detalles Bibliográficos
Autores principales: Aigner, Karl R., Selak, Emir, Aigner, Kornelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325995/
https://www.ncbi.nlm.nih.gov/pubmed/30382368
http://dx.doi.org/10.1007/s00432-018-2784-4
_version_ 1783386223926050816
author Aigner, Karl R.
Selak, Emir
Aigner, Kornelia
author_facet Aigner, Karl R.
Selak, Emir
Aigner, Kornelia
author_sort Aigner, Karl R.
collection PubMed
description PURPOSE: Head and neck cancer treatment achieves good locoregional tumor control rates while causing severe side effects. Therapy with chemotherapeutic drugs administered intravenously is limited because either the concentrations at the tumor site are too low or the total dosages are too high. The evaluation of a technique for short-term intra-arterial infusion chemotherapy is described herein. METHODS: In a retrospective study, we reviewed the medical records of 97 patients with head and neck cancers who received short-term intra-arterial infusion chemotherapy (62 patients previously untreated, 35 patients with prior radiotherapy). All patients refused further radiotherapy. Response rates, overall survival and adverse effects were the study endpoints. The blood supply of the tumors was controlled with indigocarmine blue infusion and staining of the tumor region. RESULTS: Complete or partial response was found in 67%, 52% and 63% of previously untreated patients and in 25%, 30% and 29%, respectively, of previously irradiated patients for staging groups I–III, IVA and IVB/C. Patients with T3/T4 tumors who were previously irradiated showed a median overall survival of 9 months, and those without pretreatment showed a median overall survival of 22.5 months. None of the patients required tube feeding. No new case of dysphagia, xerostomia, or functional speech and hearing loss was reported. Pain and clinical symptoms were reduced for all patient groups. Indigocarmine staining showed reduced tumor blood supply in previously irradiated regions but good blood supply in untreated regions. CONCLUSIONS: Short-term intra-arterial infusion chemotherapy achieves promising response rates and lacks severe adverse effects. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00432-018-2784-4) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-6325995
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-63259952019-01-23 Short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life Aigner, Karl R. Selak, Emir Aigner, Kornelia J Cancer Res Clin Oncol Original Article – Clinical Oncology PURPOSE: Head and neck cancer treatment achieves good locoregional tumor control rates while causing severe side effects. Therapy with chemotherapeutic drugs administered intravenously is limited because either the concentrations at the tumor site are too low or the total dosages are too high. The evaluation of a technique for short-term intra-arterial infusion chemotherapy is described herein. METHODS: In a retrospective study, we reviewed the medical records of 97 patients with head and neck cancers who received short-term intra-arterial infusion chemotherapy (62 patients previously untreated, 35 patients with prior radiotherapy). All patients refused further radiotherapy. Response rates, overall survival and adverse effects were the study endpoints. The blood supply of the tumors was controlled with indigocarmine blue infusion and staining of the tumor region. RESULTS: Complete or partial response was found in 67%, 52% and 63% of previously untreated patients and in 25%, 30% and 29%, respectively, of previously irradiated patients for staging groups I–III, IVA and IVB/C. Patients with T3/T4 tumors who were previously irradiated showed a median overall survival of 9 months, and those without pretreatment showed a median overall survival of 22.5 months. None of the patients required tube feeding. No new case of dysphagia, xerostomia, or functional speech and hearing loss was reported. Pain and clinical symptoms were reduced for all patient groups. Indigocarmine staining showed reduced tumor blood supply in previously irradiated regions but good blood supply in untreated regions. CONCLUSIONS: Short-term intra-arterial infusion chemotherapy achieves promising response rates and lacks severe adverse effects. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00432-018-2784-4) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-10-31 2019 /pmc/articles/PMC6325995/ /pubmed/30382368 http://dx.doi.org/10.1007/s00432-018-2784-4 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article – Clinical Oncology
Aigner, Karl R.
Selak, Emir
Aigner, Kornelia
Short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life
title Short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life
title_full Short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life
title_fullStr Short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life
title_full_unstemmed Short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life
title_short Short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life
title_sort short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life
topic Original Article – Clinical Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325995/
https://www.ncbi.nlm.nih.gov/pubmed/30382368
http://dx.doi.org/10.1007/s00432-018-2784-4
work_keys_str_mv AT aignerkarlr shorttermintraarterialinfusionchemotherapyforheadandneckcancerpatientsmaintainingqualityoflife
AT selakemir shorttermintraarterialinfusionchemotherapyforheadandneckcancerpatientsmaintainingqualityoflife
AT aignerkornelia shorttermintraarterialinfusionchemotherapyforheadandneckcancerpatientsmaintainingqualityoflife