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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma

PURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO(2))-Pro-Lys-Thr-OCH(3)]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocyt...

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Detalles Bibliográficos
Autores principales: Cichorek, Miroslawa, Ronowska, Anna, Gensicka-Kowalewska, Monika, Deptula, Milena, Pelikant-Malecka, Iwona, Dzierzbicka, Krystyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326014/
https://www.ncbi.nlm.nih.gov/pubmed/30367436
http://dx.doi.org/10.1007/s00432-018-2776-4