Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana

Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3–8) and anthraquinones (9–10) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectro...

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Detalles Bibliográficos
Autores principales: Kaennakam, Sutin, Mudsing, Kamonwan, Rassamee, Kitiya, Siripong, Pongpun, Tip-pyang, Santi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326088/
https://www.ncbi.nlm.nih.gov/pubmed/30171417
http://dx.doi.org/10.1007/s11418-018-1240-8
Descripción
Sumario:Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3–8) and anthraquinones (9–10) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compounds 3–6 and 8 showed good cytotoxicity against all the five cancer cell lines with IC(50) values in the range of 1.45–9.46 µM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11418-018-1240-8) contains supplementary material, which is available to authorized users.

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