Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana

Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3–8) and anthraquinones (9–10) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectro...

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Autores principales: Kaennakam, Sutin, Mudsing, Kamonwan, Rassamee, Kitiya, Siripong, Pongpun, Tip-pyang, Santi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326088/
https://www.ncbi.nlm.nih.gov/pubmed/30171417
http://dx.doi.org/10.1007/s11418-018-1240-8
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author Kaennakam, Sutin
Mudsing, Kamonwan
Rassamee, Kitiya
Siripong, Pongpun
Tip-pyang, Santi
author_facet Kaennakam, Sutin
Mudsing, Kamonwan
Rassamee, Kitiya
Siripong, Pongpun
Tip-pyang, Santi
author_sort Kaennakam, Sutin
collection PubMed
description Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3–8) and anthraquinones (9–10) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compounds 3–6 and 8 showed good cytotoxicity against all the five cancer cell lines with IC(50) values in the range of 1.45–9.46 µM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11418-018-1240-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-63260882019-02-01 Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana Kaennakam, Sutin Mudsing, Kamonwan Rassamee, Kitiya Siripong, Pongpun Tip-pyang, Santi J Nat Med Note Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3–8) and anthraquinones (9–10) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compounds 3–6 and 8 showed good cytotoxicity against all the five cancer cell lines with IC(50) values in the range of 1.45–9.46 µM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11418-018-1240-8) contains supplementary material, which is available to authorized users. Springer Singapore 2018-08-31 2019 /pmc/articles/PMC6326088/ /pubmed/30171417 http://dx.doi.org/10.1007/s11418-018-1240-8 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Note
Kaennakam, Sutin
Mudsing, Kamonwan
Rassamee, Kitiya
Siripong, Pongpun
Tip-pyang, Santi
Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana
title Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana
title_full Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana
title_fullStr Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana
title_full_unstemmed Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana
title_short Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana
title_sort two new xanthones and cytotoxicity from the bark of garcinia schomburgkiana
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326088/
https://www.ncbi.nlm.nih.gov/pubmed/30171417
http://dx.doi.org/10.1007/s11418-018-1240-8
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