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APOBEC3G expression and HIV-1 infection in Burkina Faso
APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evalu...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326155/ https://www.ncbi.nlm.nih.gov/pubmed/30687488 http://dx.doi.org/10.4081/jphia.2018.907 |
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author | Compaore, Tegwinde Rebeca Soubeiga, Serge Theophile Ouattara, Abdoul Karim Tchelougou, Damehan Bisseye, Cyrille Bakouan, Didier Romuald Compaore, Issaka Dembele, Augustine Yonli, Albert Theophane Obiri-Yeboah, Dorcas Djigma, Wendkuuni Florencia Simpore, Jacques |
author_facet | Compaore, Tegwinde Rebeca Soubeiga, Serge Theophile Ouattara, Abdoul Karim Tchelougou, Damehan Bisseye, Cyrille Bakouan, Didier Romuald Compaore, Issaka Dembele, Augustine Yonli, Albert Theophane Obiri-Yeboah, Dorcas Djigma, Wendkuuni Florencia Simpore, Jacques |
author_sort | Compaore, Tegwinde Rebeca |
collection | PubMed |
description | APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination. |
format | Online Article Text |
id | pubmed-6326155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-63261552019-01-25 APOBEC3G expression and HIV-1 infection in Burkina Faso Compaore, Tegwinde Rebeca Soubeiga, Serge Theophile Ouattara, Abdoul Karim Tchelougou, Damehan Bisseye, Cyrille Bakouan, Didier Romuald Compaore, Issaka Dembele, Augustine Yonli, Albert Theophane Obiri-Yeboah, Dorcas Djigma, Wendkuuni Florencia Simpore, Jacques J Public Health Afr Article APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination. PAGEPress Publications, Pavia, Italy 2018-12-21 /pmc/articles/PMC6326155/ /pubmed/30687488 http://dx.doi.org/10.4081/jphia.2018.907 Text en ©Copyright T.R. Compaore et al., 2018 http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution NonCommercial 4.0 License (CC BY-NC 4.0). |
spellingShingle | Article Compaore, Tegwinde Rebeca Soubeiga, Serge Theophile Ouattara, Abdoul Karim Tchelougou, Damehan Bisseye, Cyrille Bakouan, Didier Romuald Compaore, Issaka Dembele, Augustine Yonli, Albert Theophane Obiri-Yeboah, Dorcas Djigma, Wendkuuni Florencia Simpore, Jacques APOBEC3G expression and HIV-1 infection in Burkina Faso |
title | APOBEC3G expression and HIV-1 infection in Burkina Faso |
title_full | APOBEC3G expression and HIV-1 infection in Burkina Faso |
title_fullStr | APOBEC3G expression and HIV-1 infection in Burkina Faso |
title_full_unstemmed | APOBEC3G expression and HIV-1 infection in Burkina Faso |
title_short | APOBEC3G expression and HIV-1 infection in Burkina Faso |
title_sort | apobec3g expression and hiv-1 infection in burkina faso |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326155/ https://www.ncbi.nlm.nih.gov/pubmed/30687488 http://dx.doi.org/10.4081/jphia.2018.907 |
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