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APOBEC3G expression and HIV-1 infection in Burkina Faso

APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evalu...

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Autores principales: Compaore, Tegwinde Rebeca, Soubeiga, Serge Theophile, Ouattara, Abdoul Karim, Tchelougou, Damehan, Bisseye, Cyrille, Bakouan, Didier Romuald, Compaore, Issaka, Dembele, Augustine, Yonli, Albert Theophane, Obiri-Yeboah, Dorcas, Djigma, Wendkuuni Florencia, Simpore, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326155/
https://www.ncbi.nlm.nih.gov/pubmed/30687488
http://dx.doi.org/10.4081/jphia.2018.907
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author Compaore, Tegwinde Rebeca
Soubeiga, Serge Theophile
Ouattara, Abdoul Karim
Tchelougou, Damehan
Bisseye, Cyrille
Bakouan, Didier Romuald
Compaore, Issaka
Dembele, Augustine
Yonli, Albert Theophane
Obiri-Yeboah, Dorcas
Djigma, Wendkuuni Florencia
Simpore, Jacques
author_facet Compaore, Tegwinde Rebeca
Soubeiga, Serge Theophile
Ouattara, Abdoul Karim
Tchelougou, Damehan
Bisseye, Cyrille
Bakouan, Didier Romuald
Compaore, Issaka
Dembele, Augustine
Yonli, Albert Theophane
Obiri-Yeboah, Dorcas
Djigma, Wendkuuni Florencia
Simpore, Jacques
author_sort Compaore, Tegwinde Rebeca
collection PubMed
description APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination.
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spelling pubmed-63261552019-01-25 APOBEC3G expression and HIV-1 infection in Burkina Faso Compaore, Tegwinde Rebeca Soubeiga, Serge Theophile Ouattara, Abdoul Karim Tchelougou, Damehan Bisseye, Cyrille Bakouan, Didier Romuald Compaore, Issaka Dembele, Augustine Yonli, Albert Theophane Obiri-Yeboah, Dorcas Djigma, Wendkuuni Florencia Simpore, Jacques J Public Health Afr Article APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination. PAGEPress Publications, Pavia, Italy 2018-12-21 /pmc/articles/PMC6326155/ /pubmed/30687488 http://dx.doi.org/10.4081/jphia.2018.907 Text en ©Copyright T.R. Compaore et al., 2018 http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution NonCommercial 4.0 License (CC BY-NC 4.0).
spellingShingle Article
Compaore, Tegwinde Rebeca
Soubeiga, Serge Theophile
Ouattara, Abdoul Karim
Tchelougou, Damehan
Bisseye, Cyrille
Bakouan, Didier Romuald
Compaore, Issaka
Dembele, Augustine
Yonli, Albert Theophane
Obiri-Yeboah, Dorcas
Djigma, Wendkuuni Florencia
Simpore, Jacques
APOBEC3G expression and HIV-1 infection in Burkina Faso
title APOBEC3G expression and HIV-1 infection in Burkina Faso
title_full APOBEC3G expression and HIV-1 infection in Burkina Faso
title_fullStr APOBEC3G expression and HIV-1 infection in Burkina Faso
title_full_unstemmed APOBEC3G expression and HIV-1 infection in Burkina Faso
title_short APOBEC3G expression and HIV-1 infection in Burkina Faso
title_sort apobec3g expression and hiv-1 infection in burkina faso
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326155/
https://www.ncbi.nlm.nih.gov/pubmed/30687488
http://dx.doi.org/10.4081/jphia.2018.907
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