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Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis
BACKGROUND/AIMS: The effect of dietary micronutrients on non-erosive reflux disease (NERD) and reflux esophagitis is unclear. We aim to evaluate the gender-specific effect of micronutrient on erosive esophagitis and NERD. METHODS: A total of 11 690 participants underwent endoscopy and completed 3-da...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Neurogastroenterology and Motility
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326192/ https://www.ncbi.nlm.nih.gov/pubmed/30646479 http://dx.doi.org/10.5056/jnm18114 |
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author | Nam, Su Youn Park, Bum Joon Cho, Yeong-Ah Ryu, Kum Hei |
author_facet | Nam, Su Youn Park, Bum Joon Cho, Yeong-Ah Ryu, Kum Hei |
author_sort | Nam, Su Youn |
collection | PubMed |
description | BACKGROUND/AIMS: The effect of dietary micronutrients on non-erosive reflux disease (NERD) and reflux esophagitis is unclear. We aim to evaluate the gender-specific effect of micronutrient on erosive esophagitis and NERD. METHODS: A total of 11 690 participants underwent endoscopy and completed 3-day recordings for dietary intake and questionnaires for reflux symptoms from 2004 to 2008. To evaluate the effect of dietary micronutrients on NERD or erosive esophagitis, adjusted regression analysis with odds ratio (OR) and 95% confidence interval (CI) was used. In addition, we performed gender-specific analysis. RESULTS: Prevalence of NERD and erosive esophagitis was 6.8% and 11.2% in men and 9.1% and 2.4% in women. In adjusted analysis, high intake of vitamin A (OR, 0.78; 95% CI, 0.64–0.96), retinol (OR, 0.73; 95% CI, 0.59–0.90), vitamin B2 (OR, 0.68; 95% CI, 0.54–0.87), vitamin B6 (OR, 0.75; 95% CI, 0.58–0.96), folic acid (OR, 0.77; 95% CI, 0.62–0.96), calcium (OR, 0.66; 95% CI, 0.53–0.82), and iron (OR, 0.68; 95% CI, 0.53–0.87) had an inverse association with NERD. However, erosive esophagitis has no relationship with micronutrients except vitamin C (OR, 0.78; 95% CI, 0.62–0.98). High dietary intake of calcium reduced the risk of NERD in men and high dietary intake of many micronutrients reduced NERD in women. CONCLUSIONS: While many dietary micronutrients reduced NERD, they had no effect on erosive esophagitis. The effect of micronutrient on NERD was more prominent in women than men. |
format | Online Article Text |
id | pubmed-6326192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Society of Neurogastroenterology and Motility |
record_format | MEDLINE/PubMed |
spelling | pubmed-63261922019-01-11 Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis Nam, Su Youn Park, Bum Joon Cho, Yeong-Ah Ryu, Kum Hei J Neurogastroenterol Motil Original Article BACKGROUND/AIMS: The effect of dietary micronutrients on non-erosive reflux disease (NERD) and reflux esophagitis is unclear. We aim to evaluate the gender-specific effect of micronutrient on erosive esophagitis and NERD. METHODS: A total of 11 690 participants underwent endoscopy and completed 3-day recordings for dietary intake and questionnaires for reflux symptoms from 2004 to 2008. To evaluate the effect of dietary micronutrients on NERD or erosive esophagitis, adjusted regression analysis with odds ratio (OR) and 95% confidence interval (CI) was used. In addition, we performed gender-specific analysis. RESULTS: Prevalence of NERD and erosive esophagitis was 6.8% and 11.2% in men and 9.1% and 2.4% in women. In adjusted analysis, high intake of vitamin A (OR, 0.78; 95% CI, 0.64–0.96), retinol (OR, 0.73; 95% CI, 0.59–0.90), vitamin B2 (OR, 0.68; 95% CI, 0.54–0.87), vitamin B6 (OR, 0.75; 95% CI, 0.58–0.96), folic acid (OR, 0.77; 95% CI, 0.62–0.96), calcium (OR, 0.66; 95% CI, 0.53–0.82), and iron (OR, 0.68; 95% CI, 0.53–0.87) had an inverse association with NERD. However, erosive esophagitis has no relationship with micronutrients except vitamin C (OR, 0.78; 95% CI, 0.62–0.98). High dietary intake of calcium reduced the risk of NERD in men and high dietary intake of many micronutrients reduced NERD in women. CONCLUSIONS: While many dietary micronutrients reduced NERD, they had no effect on erosive esophagitis. The effect of micronutrient on NERD was more prominent in women than men. Korean Society of Neurogastroenterology and Motility 2019-01 2019-01-01 /pmc/articles/PMC6326192/ /pubmed/30646479 http://dx.doi.org/10.5056/jnm18114 Text en © 2019 The Korean Society of Neurogastroenterology and Motility This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Nam, Su Youn Park, Bum Joon Cho, Yeong-Ah Ryu, Kum Hei Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis |
title | Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis |
title_full | Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis |
title_fullStr | Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis |
title_full_unstemmed | Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis |
title_short | Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis |
title_sort | gender-specific effect of micronutrient on non-erosive reflux disease and erosive esophagitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326192/ https://www.ncbi.nlm.nih.gov/pubmed/30646479 http://dx.doi.org/10.5056/jnm18114 |
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