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Duration of a minor epidemic
Disease outbreaks in stochastic SIR epidemic models are characterized as either minor or major. When [Formula: see text] , all epidemics are minor, whereas if [Formula: see text] , they can be minor or major. In 1955, Whittle derived formulas for the probability of a minor or a major epidemic. A min...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326226/ https://www.ncbi.nlm.nih.gov/pubmed/30839911 http://dx.doi.org/10.1016/j.idm.2018.03.002 |
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author | Tritch, William Allen, Linda J.S. |
author_facet | Tritch, William Allen, Linda J.S. |
author_sort | Tritch, William |
collection | PubMed |
description | Disease outbreaks in stochastic SIR epidemic models are characterized as either minor or major. When [Formula: see text] , all epidemics are minor, whereas if [Formula: see text] , they can be minor or major. In 1955, Whittle derived formulas for the probability of a minor or a major epidemic. A minor epidemic is distinguished from a major one in that a minor epidemic is generally of shorter duration and has substantially fewer cases than a major epidemic. In this investigation, analytical formulas are derived that approximate the probability density, the mean, and the higher-order moments for the duration of a minor epidemic. These analytical results are applicable to minor epidemics in stochastic SIR, SIS, and SIRS models with a single infected class. The probability density for minor epidemics in more complex epidemic models can be computed numerically applying multitype branching processes and the backward Kolmogorov differential equations. When [Formula: see text] is close to one, minor epidemics are more common than major epidemics and their duration is significantly longer than when [Formula: see text] or [Formula: see text]. |
format | Online Article Text |
id | pubmed-6326226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-63262262019-01-18 Duration of a minor epidemic Tritch, William Allen, Linda J.S. Infect Dis Model Original Research Article Disease outbreaks in stochastic SIR epidemic models are characterized as either minor or major. When [Formula: see text] , all epidemics are minor, whereas if [Formula: see text] , they can be minor or major. In 1955, Whittle derived formulas for the probability of a minor or a major epidemic. A minor epidemic is distinguished from a major one in that a minor epidemic is generally of shorter duration and has substantially fewer cases than a major epidemic. In this investigation, analytical formulas are derived that approximate the probability density, the mean, and the higher-order moments for the duration of a minor epidemic. These analytical results are applicable to minor epidemics in stochastic SIR, SIS, and SIRS models with a single infected class. The probability density for minor epidemics in more complex epidemic models can be computed numerically applying multitype branching processes and the backward Kolmogorov differential equations. When [Formula: see text] is close to one, minor epidemics are more common than major epidemics and their duration is significantly longer than when [Formula: see text] or [Formula: see text]. KeAi Publishing 2018-03-22 /pmc/articles/PMC6326226/ /pubmed/30839911 http://dx.doi.org/10.1016/j.idm.2018.03.002 Text en © 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Article Tritch, William Allen, Linda J.S. Duration of a minor epidemic |
title | Duration of a minor epidemic |
title_full | Duration of a minor epidemic |
title_fullStr | Duration of a minor epidemic |
title_full_unstemmed | Duration of a minor epidemic |
title_short | Duration of a minor epidemic |
title_sort | duration of a minor epidemic |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326226/ https://www.ncbi.nlm.nih.gov/pubmed/30839911 http://dx.doi.org/10.1016/j.idm.2018.03.002 |
work_keys_str_mv | AT tritchwilliam durationofaminorepidemic AT allenlindajs durationofaminorepidemic |