Long non-coding RNAs in hematopoietic regulation

Long non-coding RNAs (lncRNAs) have crucial roles via tethering with DNA, RNA or protein in diverse biological processes. These lncRNA-mediated interactions enhance gene regulatory networks and modulate a wide range of downstream genes. It has been demonstrated that several lncRNAs act as key regula...

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Detalles Bibliográficos
Autores principales: Li, Weiqian, Ren, Yue, Si, Yanmin, Wang, Fang, Yu, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Society for Cell Biology 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326246/
https://www.ncbi.nlm.nih.gov/pubmed/30671227
http://dx.doi.org/10.1016/j.cr.2018.08.001
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author Li, Weiqian
Ren, Yue
Si, Yanmin
Wang, Fang
Yu, Jia
author_facet Li, Weiqian
Ren, Yue
Si, Yanmin
Wang, Fang
Yu, Jia
author_sort Li, Weiqian
collection PubMed
description Long non-coding RNAs (lncRNAs) have crucial roles via tethering with DNA, RNA or protein in diverse biological processes. These lncRNA-mediated interactions enhance gene regulatory networks and modulate a wide range of downstream genes. It has been demonstrated that several lncRNAs act as key regulators in hematopoiesis. This review highlights the roles of lncRNAs in normal hematopoietic development and discusses how lncRNA dysregulation correlates with disease prognoses and phenotypes.
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spelling pubmed-63262462019-01-22 Long non-coding RNAs in hematopoietic regulation Li, Weiqian Ren, Yue Si, Yanmin Wang, Fang Yu, Jia Cell Regen Article Long non-coding RNAs (lncRNAs) have crucial roles via tethering with DNA, RNA or protein in diverse biological processes. These lncRNA-mediated interactions enhance gene regulatory networks and modulate a wide range of downstream genes. It has been demonstrated that several lncRNAs act as key regulators in hematopoiesis. This review highlights the roles of lncRNAs in normal hematopoietic development and discusses how lncRNA dysregulation correlates with disease prognoses and phenotypes. Chinese Society for Cell Biology 2018-10-11 /pmc/articles/PMC6326246/ /pubmed/30671227 http://dx.doi.org/10.1016/j.cr.2018.08.001 Text en © 2018 Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Li, Weiqian
Ren, Yue
Si, Yanmin
Wang, Fang
Yu, Jia
Long non-coding RNAs in hematopoietic regulation
title Long non-coding RNAs in hematopoietic regulation
title_full Long non-coding RNAs in hematopoietic regulation
title_fullStr Long non-coding RNAs in hematopoietic regulation
title_full_unstemmed Long non-coding RNAs in hematopoietic regulation
title_short Long non-coding RNAs in hematopoietic regulation
title_sort long non-coding rnas in hematopoietic regulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326246/
https://www.ncbi.nlm.nih.gov/pubmed/30671227
http://dx.doi.org/10.1016/j.cr.2018.08.001
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AT siyanmin longnoncodingrnasinhematopoieticregulation
AT wangfang longnoncodingrnasinhematopoieticregulation
AT yujia longnoncodingrnasinhematopoieticregulation

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