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ACT Values after Neutralization Lower than Pre-heparinization ACT Leads to Lower Operative Times, Bleeding, and Post-Operative Transfusions in CABG Patients: an Observational Study
OBJECTIVE: To evaluate if lower activated coagulation time (ACT) value after neutralization than preoperative ACT value was effective in reducing bleeding, operative times, and post-operative transfusions in patients underwent coronary artery bypass grafting (CABG). METHODS: Retrospective selection...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cirurgia Cardiovascular
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326448/ https://www.ncbi.nlm.nih.gov/pubmed/30652748 http://dx.doi.org/10.21470/1678-9741-2018-0116 |
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author | Wang, Weitie Wang, Yongwang Wang, Jinshan Xu, Rihao Chai, Junwu Zhou, Wei Chen, Honglei Xue, Fenlong Kong, Xiangrong Kai, Wang |
author_facet | Wang, Weitie Wang, Yongwang Wang, Jinshan Xu, Rihao Chai, Junwu Zhou, Wei Chen, Honglei Xue, Fenlong Kong, Xiangrong Kai, Wang |
author_sort | Wang, Weitie |
collection | PubMed |
description | OBJECTIVE: To evaluate if lower activated coagulation time (ACT) value after neutralization than preoperative ACT value was effective in reducing bleeding, operative times, and post-operative transfusions in patients underwent coronary artery bypass grafting (CABG). METHODS: Retrospective selection of 398 patients from January 2014 to May 2017. Patients were divided into 2 groups according to final ACT after neutralization: A - final ACT lower than preoperative ACT; and B - final ACT higher than or equal to preoperative ACT. Hemostatic time, intraoperative blood loss, ACT after final neutralization, mediastinal blood loss, and transfusion requirements were observed. RESULTS: The hourly blood loss in the Group A was generally lower than in the Group B at first 3 hours, which has significant difference (P<0.05). However, there was no difference after 3 hours between the two groups. Operative time, intraoperative blood loss, mediastinal blood loss, transfusion requirements, and drainage in the first postoperative 12 hours in the Group A were lower than in Group B, which has significant difference (P<0.05). CONCLUSION: As a result, final ACT values lower than pre-heparinization ACT values are safe and lead to lower operative times, bleeding, and post-operative transfusions. |
format | Online Article Text |
id | pubmed-6326448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
record_format | MEDLINE/PubMed |
spelling | pubmed-63264482019-01-14 ACT Values after Neutralization Lower than Pre-heparinization ACT Leads to Lower Operative Times, Bleeding, and Post-Operative Transfusions in CABG Patients: an Observational Study Wang, Weitie Wang, Yongwang Wang, Jinshan Xu, Rihao Chai, Junwu Zhou, Wei Chen, Honglei Xue, Fenlong Kong, Xiangrong Kai, Wang Braz J Cardiovasc Surg Original Article OBJECTIVE: To evaluate if lower activated coagulation time (ACT) value after neutralization than preoperative ACT value was effective in reducing bleeding, operative times, and post-operative transfusions in patients underwent coronary artery bypass grafting (CABG). METHODS: Retrospective selection of 398 patients from January 2014 to May 2017. Patients were divided into 2 groups according to final ACT after neutralization: A - final ACT lower than preoperative ACT; and B - final ACT higher than or equal to preoperative ACT. Hemostatic time, intraoperative blood loss, ACT after final neutralization, mediastinal blood loss, and transfusion requirements were observed. RESULTS: The hourly blood loss in the Group A was generally lower than in the Group B at first 3 hours, which has significant difference (P<0.05). However, there was no difference after 3 hours between the two groups. Operative time, intraoperative blood loss, mediastinal blood loss, transfusion requirements, and drainage in the first postoperative 12 hours in the Group A were lower than in Group B, which has significant difference (P<0.05). CONCLUSION: As a result, final ACT values lower than pre-heparinization ACT values are safe and lead to lower operative times, bleeding, and post-operative transfusions. Sociedade Brasileira de Cirurgia Cardiovascular 2018 /pmc/articles/PMC6326448/ /pubmed/30652748 http://dx.doi.org/10.21470/1678-9741-2018-0116 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Wang, Weitie Wang, Yongwang Wang, Jinshan Xu, Rihao Chai, Junwu Zhou, Wei Chen, Honglei Xue, Fenlong Kong, Xiangrong Kai, Wang ACT Values after Neutralization Lower than Pre-heparinization ACT Leads to Lower Operative Times, Bleeding, and Post-Operative Transfusions in CABG Patients: an Observational Study |
title | ACT Values after Neutralization Lower than Pre-heparinization ACT
Leads to Lower Operative Times, Bleeding, and Post-Operative Transfusions in
CABG Patients: an Observational Study |
title_full | ACT Values after Neutralization Lower than Pre-heparinization ACT
Leads to Lower Operative Times, Bleeding, and Post-Operative Transfusions in
CABG Patients: an Observational Study |
title_fullStr | ACT Values after Neutralization Lower than Pre-heparinization ACT
Leads to Lower Operative Times, Bleeding, and Post-Operative Transfusions in
CABG Patients: an Observational Study |
title_full_unstemmed | ACT Values after Neutralization Lower than Pre-heparinization ACT
Leads to Lower Operative Times, Bleeding, and Post-Operative Transfusions in
CABG Patients: an Observational Study |
title_short | ACT Values after Neutralization Lower than Pre-heparinization ACT
Leads to Lower Operative Times, Bleeding, and Post-Operative Transfusions in
CABG Patients: an Observational Study |
title_sort | act values after neutralization lower than pre-heparinization act
leads to lower operative times, bleeding, and post-operative transfusions in
cabg patients: an observational study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326448/ https://www.ncbi.nlm.nih.gov/pubmed/30652748 http://dx.doi.org/10.21470/1678-9741-2018-0116 |
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