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Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography

Human butyrylcholinesterase (HuBChE) is being developed as a therapeutic for protection from the toxicity of nerve agents. An enriched source of HuBChE is Cohn fraction IV-4 from pooled human plasma. For the past 40 years, purification of HuBChE has included affinity chromatography on procainamide-S...

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Detalles Bibliográficos
Autores principales:	Schopfer, Lawrence M., Lockridge, Oksana, David, Emilie, Hinrichs, Steven H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326467/ https://www.ncbi.nlm.nih.gov/pubmed/30625168 http://dx.doi.org/10.1371/journal.pone.0209795

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