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Measures of possible allostatic load in comorbid cocaine and alcohol use disorder: Brain white matter integrity, telomere length, and anti-saccade performance

Chronic cocaine and alcohol use impart significant stress on biological and cognitive systems, resulting in changes consistent with an allostatic load model of neurocognitive impairment. The present study measured potential markers of allostatic load in individuals with comorbid cocaine/alcohol use...

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Autores principales: Tannous, Jonika, Mwangi, Benson, Hasan, Khader M., Narayana, Ponnada A., Steinberg, Joel L., Walss-Bass, Consuelo, Moeller, F. Gerard, Schmitz, Joy M., Lane, Scott D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326479/
https://www.ncbi.nlm.nih.gov/pubmed/30625144
http://dx.doi.org/10.1371/journal.pone.0199729
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author Tannous, Jonika
Mwangi, Benson
Hasan, Khader M.
Narayana, Ponnada A.
Steinberg, Joel L.
Walss-Bass, Consuelo
Moeller, F. Gerard
Schmitz, Joy M.
Lane, Scott D.
author_facet Tannous, Jonika
Mwangi, Benson
Hasan, Khader M.
Narayana, Ponnada A.
Steinberg, Joel L.
Walss-Bass, Consuelo
Moeller, F. Gerard
Schmitz, Joy M.
Lane, Scott D.
author_sort Tannous, Jonika
collection PubMed
description Chronic cocaine and alcohol use impart significant stress on biological and cognitive systems, resulting in changes consistent with an allostatic load model of neurocognitive impairment. The present study measured potential markers of allostatic load in individuals with comorbid cocaine/alcohol use disorders (CUD/AUD) and control subjects. Measures of brain white matter (WM), telomere length, and impulsivity/attentional bias were obtained. WM (CUD/AUD only) was indexed by diffusion tensor imaging metrics, including radial diffusivity (RD) and fractional anisotropy (FA). Telomere length was indexed by the telomere to single copy gene (T/S) ratio. Impulsivity and attentional bias to drug cues were measured via eye-tracking, and were also modeled using the Hierarchical Diffusion Drift Model (HDDM). Average whole-brain RD and FA were associated with years of cocaine use (R(2) = 0.56 and 0.51, both p < .005) but not years of alcohol use. CUD/AUD subjects showed more anti-saccade errors (p < .01), greater attentional bias scores (p < .001), and higher HDDM drift rates on cocaine-cue trials (Bayesian probability CUD/AUD > control = p > 0.99). Telomere length was shorter in CUD/AUD, but the difference was not statistically significant. Within the CUD/AUD group, exploratory regression using an elastic-net model determined that more years of cocaine use, older age, larger HDDM drift rate differences and shorter telomere length were all predictive of WM as measured by RD (model R(2) = 0.79). Collectively, the results provide modest support linking CUD/AUD to putative markers of allostatic load.
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spelling pubmed-63264792019-01-19 Measures of possible allostatic load in comorbid cocaine and alcohol use disorder: Brain white matter integrity, telomere length, and anti-saccade performance Tannous, Jonika Mwangi, Benson Hasan, Khader M. Narayana, Ponnada A. Steinberg, Joel L. Walss-Bass, Consuelo Moeller, F. Gerard Schmitz, Joy M. Lane, Scott D. PLoS One Research Article Chronic cocaine and alcohol use impart significant stress on biological and cognitive systems, resulting in changes consistent with an allostatic load model of neurocognitive impairment. The present study measured potential markers of allostatic load in individuals with comorbid cocaine/alcohol use disorders (CUD/AUD) and control subjects. Measures of brain white matter (WM), telomere length, and impulsivity/attentional bias were obtained. WM (CUD/AUD only) was indexed by diffusion tensor imaging metrics, including radial diffusivity (RD) and fractional anisotropy (FA). Telomere length was indexed by the telomere to single copy gene (T/S) ratio. Impulsivity and attentional bias to drug cues were measured via eye-tracking, and were also modeled using the Hierarchical Diffusion Drift Model (HDDM). Average whole-brain RD and FA were associated with years of cocaine use (R(2) = 0.56 and 0.51, both p < .005) but not years of alcohol use. CUD/AUD subjects showed more anti-saccade errors (p < .01), greater attentional bias scores (p < .001), and higher HDDM drift rates on cocaine-cue trials (Bayesian probability CUD/AUD > control = p > 0.99). Telomere length was shorter in CUD/AUD, but the difference was not statistically significant. Within the CUD/AUD group, exploratory regression using an elastic-net model determined that more years of cocaine use, older age, larger HDDM drift rate differences and shorter telomere length were all predictive of WM as measured by RD (model R(2) = 0.79). Collectively, the results provide modest support linking CUD/AUD to putative markers of allostatic load. Public Library of Science 2019-01-09 /pmc/articles/PMC6326479/ /pubmed/30625144 http://dx.doi.org/10.1371/journal.pone.0199729 Text en © 2019 Tannous et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tannous, Jonika
Mwangi, Benson
Hasan, Khader M.
Narayana, Ponnada A.
Steinberg, Joel L.
Walss-Bass, Consuelo
Moeller, F. Gerard
Schmitz, Joy M.
Lane, Scott D.
Measures of possible allostatic load in comorbid cocaine and alcohol use disorder: Brain white matter integrity, telomere length, and anti-saccade performance
title Measures of possible allostatic load in comorbid cocaine and alcohol use disorder: Brain white matter integrity, telomere length, and anti-saccade performance
title_full Measures of possible allostatic load in comorbid cocaine and alcohol use disorder: Brain white matter integrity, telomere length, and anti-saccade performance
title_fullStr Measures of possible allostatic load in comorbid cocaine and alcohol use disorder: Brain white matter integrity, telomere length, and anti-saccade performance
title_full_unstemmed Measures of possible allostatic load in comorbid cocaine and alcohol use disorder: Brain white matter integrity, telomere length, and anti-saccade performance
title_short Measures of possible allostatic load in comorbid cocaine and alcohol use disorder: Brain white matter integrity, telomere length, and anti-saccade performance
title_sort measures of possible allostatic load in comorbid cocaine and alcohol use disorder: brain white matter integrity, telomere length, and anti-saccade performance
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326479/
https://www.ncbi.nlm.nih.gov/pubmed/30625144
http://dx.doi.org/10.1371/journal.pone.0199729
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