Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection

Innate immune response against Brucella abortus involves activation of Toll-like receptors (TLRs) and NOD-like receptors (NLRs). Among the NLRs involved in the recognition of B. abortus are NLRP3 and AIM2. Here, we demonstrate that B. abortus triggers non-canonical inflammasome activation dependent...

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Detalles Bibliográficos
Autores principales: Cerqueira, Daiane M., Gomes, Marco Túlio R., Silva, Alexandre L. N., Rungue, Marcella, Assis, Natan R. G., Guimarães, Erika S., Morais, Suellen B., Broz, Petr, Zamboni, Dario S., Oliveira, Sergio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326519/
https://www.ncbi.nlm.nih.gov/pubmed/30589883
http://dx.doi.org/10.1371/journal.ppat.1007519

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