A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

Werner syndrome (WS), an autosomal recessive genetic disorder, displays accelerated clinical symptoms of aging leading to a mean lifespan less than 50 years. The WS helicase-nuclease (WRN) is involved in many important pathways including DNA replication, recombination and repair. Replicating cells a...

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Detalles Bibliográficos
Autores principales: Sommers, Joshua A., Kulikowicz, Tomasz, Croteau, Deborah L., Dexheimer, Thomas, Dorjsuren, Dorjbal, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Bohr, Vilhelm A., Brosh, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326523/
https://www.ncbi.nlm.nih.gov/pubmed/30625228
http://dx.doi.org/10.1371/journal.pone.0210525

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