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A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension

[Image: see text] A working model of nonenzymatic RNA primer extension could illuminate how prebiotic chemistry transitioned to biology. All currently known experimental reconstructions of nonenzymatic RNA primer extension yield a mixture of 2′-5′ and 3′-5′ internucleotide linkages. Although long se...

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Detalles Bibliográficos
Autores principales:	Giurgiu, Constantin, Li, Li, O’Flaherty, Derek K., Tam, Chun Pong, Szostak, Jack W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326530/ https://www.ncbi.nlm.nih.gov/pubmed/29112424 http://dx.doi.org/10.1021/jacs.7b08784

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