Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension

[Image: see text] We report the synthesis of guanosine 5′-(4-methylimidazolyl)phosphonate (ICG), the third member of a series of nonhydrolyzable nucleoside 5′-phosphoro-2-methylimidazolide (2-MeImpN) analogues designed for mechanistic studies of nonenzymatic RNA primer extension. The addition of a 2...

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Detalles Bibliográficos
Autores principales: Tam, Chun Pong, Zhou, Lijun, Fahrenbach, Albert C., Zhang, Wen, Walton, Travis, Szostak, Jack W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326531/
https://www.ncbi.nlm.nih.gov/pubmed/29251930
http://dx.doi.org/10.1021/jacs.7b11623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326531/
https://www.ncbi.nlm.nih.gov/pubmed/29251930
http://dx.doi.org/10.1021/jacs.7b11623

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