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Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma

An altered metabolism is involved in the development of clear cell - renal cell carcinoma (ccRCC), and in this tumor many altered genes play a fundamental role in controlling cell metabolic activities. We delineated a large-scale metabolomic profile of human ccRCC, and integrated it with transcripto...

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Detalles Bibliográficos
Autores principales:	Lucarelli, Giuseppe, Rutigliano, Monica, Sallustio, Fabio, Ribatti, Domenico, Giglio, Andrea, Signorile, Martina Lepore, Grossi, Valentina, Sanese, Paola, Napoli, Anna, Maiorano, Eugenio, Bianchi, Cristina, Perego, Roberto A., Ferro, Matteo, Ranieri, Elena, Serino, Grazia, Bell, Lauren N., Ditonno, Pasquale, Simone, Cristiano, Battaglia, Michele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326659/ https://www.ncbi.nlm.nih.gov/pubmed/30538212 http://dx.doi.org/10.18632/aging.101685

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