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Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity
The rules governing cerebellar output are not fully understood, but must involve Purkinje cell (PC) activity, as PCs are the major input to deep cerebellar nuclear (DCN) cells (which form the majority of cerebellar output). Here, the influence of PC complex spikes (CSs) was investigated by simultane...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326725/ https://www.ncbi.nlm.nih.gov/pubmed/30624204 http://dx.doi.org/10.7554/eLife.40101 |
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author | Tang, Tianyu Blenkinsop, Timothy A Lang, Eric J |
author_facet | Tang, Tianyu Blenkinsop, Timothy A Lang, Eric J |
author_sort | Tang, Tianyu |
collection | PubMed |
description | The rules governing cerebellar output are not fully understood, but must involve Purkinje cell (PC) activity, as PCs are the major input to deep cerebellar nuclear (DCN) cells (which form the majority of cerebellar output). Here, the influence of PC complex spikes (CSs) was investigated by simultaneously recording DCN activity with CSs from PC arrays in anesthetized rats. Crosscorrelograms were used to identify PCs that were presynaptic to recorded DCN cells (presynaptic PCs). Such PCs were located within rostrocaudal cortical strips and displayed synchronous CS activity. CS-associated modulation of DCN activity included a short-latency post-CS inhibition and long-latency excitations before and after the CS. The amplitudes of the post-CS responses correlated with the level of synchronization among presynaptic PCs. A temporal precision of ≤10 ms was generally required for CSs to be maximally effective. The results suggest that CS synchrony is a key control parameter of cerebellar output. Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter). |
format | Online Article Text |
id | pubmed-6326725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-63267252019-01-11 Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity Tang, Tianyu Blenkinsop, Timothy A Lang, Eric J eLife Neuroscience The rules governing cerebellar output are not fully understood, but must involve Purkinje cell (PC) activity, as PCs are the major input to deep cerebellar nuclear (DCN) cells (which form the majority of cerebellar output). Here, the influence of PC complex spikes (CSs) was investigated by simultaneously recording DCN activity with CSs from PC arrays in anesthetized rats. Crosscorrelograms were used to identify PCs that were presynaptic to recorded DCN cells (presynaptic PCs). Such PCs were located within rostrocaudal cortical strips and displayed synchronous CS activity. CS-associated modulation of DCN activity included a short-latency post-CS inhibition and long-latency excitations before and after the CS. The amplitudes of the post-CS responses correlated with the level of synchronization among presynaptic PCs. A temporal precision of ≤10 ms was generally required for CSs to be maximally effective. The results suggest that CS synchrony is a key control parameter of cerebellar output. Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter). eLife Sciences Publications, Ltd 2019-01-09 /pmc/articles/PMC6326725/ /pubmed/30624204 http://dx.doi.org/10.7554/eLife.40101 Text en © 2019, Tang et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Tang, Tianyu Blenkinsop, Timothy A Lang, Eric J Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity |
title | Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity |
title_full | Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity |
title_fullStr | Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity |
title_full_unstemmed | Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity |
title_short | Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity |
title_sort | complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326725/ https://www.ncbi.nlm.nih.gov/pubmed/30624204 http://dx.doi.org/10.7554/eLife.40101 |
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