Potentiation of cerebellar Purkinje cells facilitates whisker reflex adaptation through increased simple spike activity

Cerebellar plasticity underlies motor learning. However, how the cerebellum operates to enable learned changes in motor output is largely unknown. We developed a sensory-driven adaptation protocol for reflexive whisker protraction and recorded Purkinje cell activity from crus 1 and 2 of awake mice....

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Detalles Bibliográficos
Autores principales: Romano, Vincenzo, De Propris, Licia, Bosman, Laurens WJ, Warnaar, Pascal, ten Brinke, Michiel M, Lindeman, Sander, Ju, Chiheng, Velauthapillai, Arthiha, Spanke, Jochen K, Middendorp Guerra, Emily, Hoogland, Tycho M, Negrello, Mario, D'Angelo, Egidio, De Zeeuw, Chris I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326726/
https://www.ncbi.nlm.nih.gov/pubmed/30561331
http://dx.doi.org/10.7554/eLife.38852

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